DSIP

Product Details

DSIP Peptide

DSIP Peptide (Delta Sleep-Inducing Peptide) is a synthetic nonapeptide with the amino acid sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu and a molecular weight of approximately 848.82 g/mol . Also known as Emideltide or delta sleep peptide, DSIP was originally isolated from rabbit cerebral venous blood and has since become a standard research tool for investigating neuropeptide signaling and neuroendocrine regulation .

At peptidesunit.com, we supply research-grade DSIP as a sterile-filtered, lyophilized powder, batch-tested for purity and identity. Each vial is accompanied by a Certificate of Analysis (COA) confirming HPLC purity and mass spectrometry verification. DSIP Peptide 

Key Specifications

Product Description

DSIP Peptide is a naturally occurring neuropeptide found in neurons, peripheral organs, and plasma . In research settings, DSIP has been investigated for its involvement in multiple physiological pathways, including:

Neuroendocrine Signaling: DSIP has been shown to influence the release of anterior pituitary hormones, including ACTH, luteinizing hormone (LH), and growth hormone (GH) . Research indicates it may inhibit basal and stimulated ACTH secretion, suggesting a role in hypothalamic-pituitary-adrenal (HPA) axis regulation .

Sleep Architecture Research: Early studies demonstrated that DSIP administration increased slow-wave (delta) sleep in various animal models . However, more recent research presents conflicting findings regarding its sleep-promoting effects, and the precise mechanisms remain incompletely characterized .

Stress-Response Modulation: DSIP has been studied as a stress-limiting factor, with research showing increased survival rates in animal models under acute emotional stress . Studies suggest DSIP administration may normalize stress-related physiological parameters and modulate Fos expression in limbic brain regions . DSIP Peptide 

Biochemical Properties: DSIP penetrates the blood-brain barrier following peripheral administration, as demonstrated through radioimmunoassay studies . The peptide exhibits a relatively short half-life in biological systems, with proteolytic cleavage of tryptophan occurring within approximately 15 minutes in brain tissue preparations .

Research Applications

DSIP is used in laboratory settings for:

• Neuroendocrine research: Investigating HPA axis regulation and pituitary hormone release mechanisms

• Peptide signaling studies: Examining neuropeptide-receptor interactions and intracellular signaling pathways

• Analytical method development: Serving as a reference standard for HPLC and LC-MS peptide characterization

• Stress physiology research: Studying molecular mechanisms of stress adaptation and homeostasis

• Comparative peptide analysis: Investigating structure-activity relationships of DSIP analogs

Handling and Reconstitution Guidelines

Reconstitution: Reconstitute the lyophilized powder in sterile water, dilute acetic acid, or appropriate buffer solution (e.g., PBS). Avoid vigorous agitation; gently swirl or pipette to dissolve.

Storage After Reconstitution: Aliquot reconstituted peptide and store at -20°C or lower. Avoid repeated freeze-thaw cycles to maintain peptide integrity .

Stability Considerations: DSIP may exhibit limited stability in aqueous solution. Prepare fresh working solutions when possible. Buffer composition, pH, and enzymatic activity can influence peptide stability . DSIP Peptide 

Important Safety Information

For Research Use Only. This product is intended strictly for laboratory research purposes. It is not for human or veterinary use, diagnostic procedures, or therapeutic applications .

• Not a drug, dietary supplement, or medical device

• Not approved for human or veterinary administration

• Buyer must be a qualified researcher or institution

• Handle in accordance with institutional biosafety guidelines

• Proper storage, handling, and disposal are the purchaser’s responsibility

Why Buy DSIP Peptide from peptidesunit.com?

• Batch-tested purity: Every lot verified by HPLC and MS

• COA included: Certificate of Analysis provided with each order

• Fast shipping: Orders dispatched within 24-48 hours

• Research-grade quality: Manufactured under strict quality control standards

• Competitive pricing: Direct-from-supplier value