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GHK-Cu

GHK-CU

Price range: $33.00 through $65.00

GHK-Cu (Copper Tripeptide-1) — Research Grade Peptide

  • Naturally occurring copper-binding tripeptide (Gly-His-Lys-Cu²⁺)

  • Modulates collagen I/III, elastin, and glycosaminoglycan synthesis

  • ≥98% purity (HPLC), MS-confirmed identity

  • Lyophilized powder · CAS 89030-95-5 · C₁₄H₂₂CuN₆O₄

  • Lot-specific COA included

  • For research use only

99%+
Purity grade
24h
Dispatch
3rd
Party tested
Certificate of Analysis
Included with every batch
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Product Details

GHK-Cu (Copper Tripeptide-1) — Research Grade Peptide, ≥98% Purity (HPLC)

Copper-binding tripeptide. Collagen synthesis research tool. Lyophilized powder. Lot-specific COA included.

GHK-Cu (glycyl-L-histidyl-L-lysine copper complex), also known as Copper Tripeptide-1, is a naturally occurring tripeptide first isolated from human plasma in the 1970s. It is a degradation product of the α2(I) chain of type I collagen, which suggests it may be liberated by proteases at wound sites to exert local healing effects. The tripeptide forms a stable complex with copper(II) ions, and this copper coordination is essential for its biological activity.

The peptide’s research profile centers on extracellular matrix (ECM) remodeling. GHK-Cu upregulates collagen I and III, elastin, decorin, and glycosaminoglycans, modulates the MMP/TIMP balance, and supports angiogenesis. In gene-expression studies, it appears to shift cells toward a regenerative profile. Recent work in C. elegans has provided the first mechanistic evidence that GHK-Cu delays aging through coordinated regulation of mitochondrial function and activation of the DAF-16 and SKN-1 pathways.

Supplied as a sterile-filtered, lyophilized powder for in vitro and preclinical research applications. Each lot is independently verified for purity and identity and ships with a Certificate of Analysis.

Specifications

Parameter Detail
CAS Number 89030-95-5
Molecular Formula C₁₄H₂₂CuN₆O₄
Molecular Weight 401.91 g/mol
Sequence Gly-His-Lys (GHK) complexed with Cu²⁺
Purity ≥98% (HPLC)
Identity Confirmed by mass spectrometry
Appearance Blue-tinged crystalline powder
Solubility Soluble in water and aqueous buffers
Storage −20 °C, desiccated, protected from light
Format Lyophilized powder, sterile-filtered
Documentation Lot-specific COA (HPLC + MS)

Note: GHK-Cu is supplied in both free base and acetate salt forms. The acetate form has a molecular weight of 461.96 g/mol and CAS number 300801-03-0. The characteristic blue color of the powder is due to the copper coordination. Verify the exact form and molecular weight against the Certificate of Analysis supplied with your lot.

Research applications

GHK-Cu is used in laboratory settings to investigate:

  • Collagen and extracellular matrix synthesis — stimulation of collagen I and III, elastin, decorin, and glycosaminoglycan production in human dermal fibroblast cultures

  • Anti-inflammatory signaling — inhibition of neutrophil and macrophage migration, suppression of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6), and upregulation of anti-inflammatory IL-10 in zebrafish inflammation models

  • Antioxidant defense — reduction of nitric oxide (NO) and reactive oxygen species (ROS) levels, and enhanced superoxide dismutase (SOD) activity in LPS-induced inflammation models

  • Mitochondrial function and aging research — preservation of mitochondrial membrane potential, attenuation of age-related mitochondrial network fragmentation, and lifespan extension in C. elegans via DAF-16/SKN-1 pathway activation

  • Wound healing and re-epithelialization — accelerated wound closure in a Phase 2 topical gel study (CuHeal) using standardized punch-biopsy wounds in healthy adults

  • Soft tissue filler and regenerative research — GHK-Cu loaded onto hydroxyapatite microspheres for sustained release, reduced inflammation, and enhanced collagen deposition in LPS-induced inflammation models

  • Analytical method development — CE-ICP-MS/MS quantification and stability assessment of GHK-Cu in complex cosmetic matrices

Handling and storage

Reconstitute under aseptic conditions using sterile water or an appropriate aqueous buffer. GHK-Cu is soluble in water. Aliquot immediately after reconstitution to avoid repeated freeze-thaw cycles. Lyophilized powder is stable for up to 2 years at −20 °C under sealed, desiccated, light-protected conditions. Reconstituted solutions should be stored at 2–8 °C and used within 14–21 days. Do not freeze reconstituted solution.

For laboratory use by qualified personnel only.

23 reviews for GHK-CU

  1. Ava Thompson –

    Fast shipping and excellent peptide quality. Packaging was discreet and professional.

  2. Liam Carter –

    Product arrived quickly and purity matched the COA. Very reliable vendor.

  3. Sophia Nguyen –

    Good quality peptides and easy ordering process. Shipping was prompt.

  4. Noah Bennett –

    Great customer service and fast delivery. Product worked exactly as expected.

  5. Mia Rodriguez –

    Secure checkout and sterile packaging. I was impressed with the quality.

  6. Ethan Walker –

    Competitive pricing and reliable products. Delivery took a few days but was smooth.

  7. Isabella Kim –

    Excellent purity and professional service. Will definitely order again.

  8. Mason Clark –

    Batch-specific COA included and product quality was top-notch. Highly recommend.

  9. Amelia Davis –

    Good experience overall. Peptides were as described and shipping was quick.

  10. Lucas Martinez –

    Fast and discreet shipping. Product integrity was perfect and support was helpful.

  11. Harper Lewis –

    Very satisfied with the quality and speed of delivery. Trustworthy supplier.

  12. Oliver Young –

    Solid vendor with fair prices. Products arrived well packaged and on time.

  13. Evelyn Hall –

    Excellent customer support and high-quality peptides. Five stars.

  14. Elijah Allen –

    Smooth ordering and quick delivery. Purity was exactly as stated.

  15. Chloe Wright –

    Good quality and responsive support. Shipping was slightly delayed but resolved.

  16. James Scott –

    Reliable source with great COAs. Product worked perfectly in my research.

  17. Grace Baker –

    Discreet packaging and fast arrival. Very happy with the product quality.

  18. Benjamin Reed –

    Easy website and secure checkout. Peptides were high quality and well packed.

  19. Lily Morgan –

    Impressive purity and professional packaging. Highly recommend Peptides Unit.

  20. Henry Foster –

    Fast shipping and excellent customer service. Will definitely reorder.

  21. Zoe Mitchell –

    Reliable vendor with good pricing. Product arrived quickly and as described.

  22. Samuel Turner –

    Great communication and top-notch peptides. Very satisfied with my order.

  23. Nora Phillips –

    Secure packaging and fast delivery. Product quality exceeded expectations.

Add a review

23 reviews for GHK-CU

  1. Ava Thompson –

    Fast shipping and excellent peptide quality. Packaging was discreet and professional.

  2. Liam Carter –

    Product arrived quickly and purity matched the COA. Very reliable vendor.

  3. Sophia Nguyen –

    Good quality peptides and easy ordering process. Shipping was prompt.

  4. Noah Bennett –

    Great customer service and fast delivery. Product worked exactly as expected.

  5. Mia Rodriguez –

    Secure checkout and sterile packaging. I was impressed with the quality.

  6. Ethan Walker –

    Competitive pricing and reliable products. Delivery took a few days but was smooth.

  7. Isabella Kim –

    Excellent purity and professional service. Will definitely order again.

  8. Mason Clark –

    Batch-specific COA included and product quality was top-notch. Highly recommend.

  9. Amelia Davis –

    Good experience overall. Peptides were as described and shipping was quick.

  10. Lucas Martinez –

    Fast and discreet shipping. Product integrity was perfect and support was helpful.

  11. Harper Lewis –

    Very satisfied with the quality and speed of delivery. Trustworthy supplier.

  12. Oliver Young –

    Solid vendor with fair prices. Products arrived well packaged and on time.

  13. Evelyn Hall –

    Excellent customer support and high-quality peptides. Five stars.

  14. Elijah Allen –

    Smooth ordering and quick delivery. Purity was exactly as stated.

  15. Chloe Wright –

    Good quality and responsive support. Shipping was slightly delayed but resolved.

  16. James Scott –

    Reliable source with great COAs. Product worked perfectly in my research.

  17. Grace Baker –

    Discreet packaging and fast arrival. Very happy with the product quality.

  18. Benjamin Reed –

    Easy website and secure checkout. Peptides were high quality and well packed.

  19. Lily Morgan –

    Impressive purity and professional packaging. Highly recommend Peptides Unit.

  20. Henry Foster –

    Fast shipping and excellent customer service. Will definitely reorder.

  21. Zoe Mitchell –

    Reliable vendor with good pricing. Product arrived quickly and as described.

  22. Samuel Turner –

    Great communication and top-notch peptides. Very satisfied with my order.

  23. Nora Phillips –

    Secure packaging and fast delivery. Product quality exceeded expectations.

Add a review

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