Klow Peptide

Product Details

Klow Peptide Blend (GHK-Cu 50 mg + BPC-157 10 mg + TB-500 10 mg + KPV 10 mg) — Research Grade, ≥98% Purity (HPLC)

Co-lyophilized four-peptide blend. 80 mg total. Lot-specific COA included.

Klow Peptide is a research-grade blend combining four peptides with distinct, complementary mechanisms in a single 80 mg lyophilized vial. The most commonly cited formulation is a 50/10/10/10 ratio: 50 mg GHK-Cu, 10 mg BPC-157, 10 mg TB-500, and 10 mg KPV. The blend is designed for researchers investigating multi-pathway tissue repair, extracellular matrix biology, and inflammatory signaling in a single experimental system.

GHK-Cu (glycyl-L-histidyl-L-lysine copper complex) is a naturally occurring tripeptide first identified in human plasma. Its research profile centers on collagen and elastin synthesis, with studies showing it modulates approximately 4,000 human genes and stimulates collagen production in fibroblast cultures.

BPC-157 (body protection compound 157) is a synthetic 15-amino-acid pentadecapeptide derived from a partial sequence of human gastric juice protein. Its research profile centers on angiogenesis via VEGFR2-Akt-eNOS signaling and fibroblast proliferation.

TB-500 is a synthetic fragment corresponding to the active region of thymosin β4. Its research profile centers on G-actin sequestration, cell migration, and downregulation of inflammatory chemokines.

KPV (Lys-Pro-Val) is a tripeptide corresponding to the C-terminal sequence of α-melanocyte-stimulating hormone (α-MSH). Its research profile centers on anti-inflammatory signaling, with nanomolar concentrations inhibiting NF-κB activation and MAP kinase inflammatory pathways.

Supplied as a sterile-filtered, co-lyophilized powder for in vitro and preclinical research applications. Each lot is independently verified for purity and identity of all four components and ships with a Certificate of Analysis. Klow Peptide

Specifications

Note: The blue color of the powder is characteristic of the copper coordination in GHK-Cu. KLOW formulations vary between suppliers — most list 80 mg total with a 50/10/10/10 ratio, though some list different ratios or total peptide content. Verify the exact composition, ratio, and per-component purity against the Certificate of Analysis supplied with your lot. Klow Peptide

Research applications

KLOW is used in laboratory settings to investigate:

• Collagen and elastin synthesis — GHK-Cu component stimulates type I and type III collagen production, elastin synthesis, and glycosaminoglycan deposition in dermal fibroblast models

• Angiogenesis and vascular signaling — BPC-157 component upregulates VEGFR2 and activates downstream VEGFR2-Akt-eNOS signaling in endothelial cell models

• Cell migration and actin dynamics — TB-500 component lowers the actin polymerization threshold, priming cellular migration in in vitro and animal models

• Anti-inflammatory signaling — KPV component inhibits NF-κB activation and MAP kinase inflammatory pathways, reducing pro-inflammatory cytokine secretion at nanomolar concentrations

• Intestinal inflammation research — KPV has been studied in DSS-induced colitis mouse models and nanoparticle delivery systems targeting inflamed colon tissue

• Keratinocyte protection — KPV mitigates fine dust-induced keratinocyte apoptosis and inflammation by regulating oxidative stress and modulating the MAPK/NF-κB pathway

• Multi-pathway tissue repair research — the four components act at complementary stages of the repair cascade: GHK-Cu supports structural matrix synthesis, BPC-157 drives angiogenesis, TB-500 regulates cell motility, and KPV modulates inflammatory signaling

• Analytical method development — LC-MS/MS quantification and per-component reference standard preparation for multi-peptide blend analysis

Handling and storage

Reconstitute under aseptic conditions using sterile water or an appropriate aqueous buffer. The blend is soluble in water. Aliquot immediately after reconstitution to avoid repeated freeze-thaw cycles. Lyophilized powder is stable for up to 2 years at −20 °C under sealed, desiccated, light-protected conditions. Reconstituted solutions should be stored at 2–8 °C and used within 14–21 days. Do not freeze reconstituted solution. Klow Peptide

Klow Peptide For laboratory use by qualified personnel only.