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Retatrutide peptide

Retatrutide

Price range: $73.00 through $353.00

Retatrutide (LY3437943) — Research Grade Peptide

  • Triple agonist: GCGR, GIPR, and GLP-1R (EC₅₀ 5.79 / 0.0643 / 0.775 nM)

  • ≥99% purity (HPLC), MS-confirmed identity

  • Lyophilized powder · CAS 2381089-83-2 · LY3437943

  • Lot-specific COA included

  • For research use only — not for human use

99%+
Purity grade
24h
Dispatch
3rd
Party tested
Certificate of Analysis
Included with every batch
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Product Details

Retatrutide peptide (LY3437943) — Research Grade Peptide, ≥99% Purity (HPLC)

Triple GIP/GLP-1/glucagon receptor agonist. Lyophilized powder. Lot-specific COA included.

Retatrutide peptide is a synthetic 39-amino acid single-peptide triple agonist engineered to activate three G-protein–coupled receptors: glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon (GCGR). It binds human GCGR, GIPR, and GLP-1R with EC₅₀ values of 5.79 nM, 0.0643 nM, and 0.775 nM respectively, with binding affinities (Kᵢ) of 5.6 nM, 0.057 nM, and 7.2 nM. The peptide sequence incorporates non-proteinogenic amino acid substitutions (including Aib at position 2) and a C20 fatty diacid moiety conjugated via a linker to promote albumin binding and extend half-life. Retatrutide peptide

Supplied as a sterile-filtered, lyophilized powder for in vitro and preclinical research applications. Each lot is independently verified for purity and identity and ships with a Certificate of Analysis. Retatrutide peptide

Specifications

Parameter Detail
CAS Number 2381089-83-2 (free acid)
Molecular Formula C₂₂₁H₃₄₂N₄₆O₆₈
Molecular Weight 4731.33 g/mol (free acid); 4791.38 g/mol (acetate salt)
Purity ≥99% (HPLC)
Identity Confirmed by mass spectrometry
Appearance White to off-white lyophilized powder
Solubility DMSO ≥100 mg/mL; H₂O ~20–100 mg/mL with sonication and pH adjustment
Storage −20 °C (powder, 1 yr) or −80 °C (powder, 2 yr), desiccated, protected from light, under nitrogen
Format Lyophilized powder, sterile-filtered
Documentation Lot-specific COA (HPLC + MS)

Note: The acetate salt form carries a molecular weight of 4791.38 g/mol. Verify the specific salt form and reconstitution details against the Certificate of Analysis supplied with your lot.

Research applications

Retatrutide is used in laboratory settings to investigate:

  • Triple incretin receptor signaling — comparative activation of GLP-1R, GIPR, and GCGR pathways and downstream cAMP accumulation in transfected cell lines

  • Metabolic and renal fibrosis research — effects on fibrosis markers in UUO and aged mouse models, with HK-2 cell lines treated at 15 μg/mL for 48 hours

  • Oncology-adjacent metabolic research — investigation of whether metabolic dysregulation addressed by retatrutide enhances anticancer drug efficacy in obese preclinical models of triple-negative breast cancer

  • Cardiac inotropy studies — effects on isolated human atrial preparations, with retatrutide shown to raise cAMP levels in transfected cells

  • Energy expenditure and lipid metabolism — GCGR-mediated lipolysis and thermogenesis in diet-induced obese (DIO) mouse models

Handling and storage

Reconstitute under aseptic conditions. Retatrutide is soluble in DMSO at ≥100 mg/mL; aqueous solubility requires sonication with pH adjustment (pH 9 using NH₃·H₂O or pH 7 with NaOH depending on the salt form). Use fresh, anhydrous DMSO, as moisture-contaminated DMSO may reduce solubility. Aliquot immediately after reconstitution to avoid repeated freeze-thaw cycles. Lyophilized powder is stable for up to 2 years at −80 °C or 1 year at −20 °C under sealed, desiccated, light-protected conditions. Reconstituted solutions should be stored at −80 °C and are stable for approximately 6 months.

Retatrutide peptide For laboratory use by qualified personnel only.

Compliance

For research use only. Not for human or veterinary use. Not for diagnostic, therapeutic, or cosmetic use. Not for use in food, drugs, or household applications.

This product is sold exclusively to laboratories, academic institutions, and qualified research professionals for in vitro and preclinical investigation. Statements on this page have not been evaluated by the FDA. No medical claims are made or implied. By purchasing, you confirm you are 21 or older and that the product will be used solely for lawful laboratory research. Retatrutide peptide

23 reviews for Retatrutide

  1. Ava Thompson –

    Fast shipping and excellent peptide quality. Packaging was discreet and professional.

  2. Liam Carter –

    Product arrived quickly and purity matched the COA. Very reliable vendor.

  3. Sophia Nguyen –

    Good quality peptides and easy ordering process. Shipping was prompt.

  4. Noah Bennett –

    Great customer service and fast delivery. Product worked exactly as expected.

  5. Mia Rodriguez –

    Secure checkout and sterile packaging. I was impressed with the quality.

  6. Ethan Walker –

    Competitive pricing and reliable products. Delivery took a few days but was smooth.

  7. Isabella Kim –

    Excellent purity and professional service. Will definitely order again.

  8. Mason Clark –

    Batch-specific COA included and product quality was top-notch. Highly recommend.

  9. Amelia Davis –

    Good experience overall. Peptides were as described and shipping was quick.

  10. Lucas Martinez –

    Fast and discreet shipping. Product integrity was perfect and support was helpful.

  11. Harper Lewis –

    Very satisfied with the quality and speed of delivery. Trustworthy supplier.

  12. Oliver Young –

    Solid vendor with fair prices. Products arrived well packaged and on time.

  13. Evelyn Hall –

    Excellent customer support and high-quality peptides. Five stars.

  14. Elijah Allen –

    Smooth ordering and quick delivery. Purity was exactly as stated.

  15. Chloe Wright –

    Good quality and responsive support. Shipping was slightly delayed but resolved.

  16. James Scott –

    Reliable source with great COAs. Product worked perfectly in my research.

  17. Grace Baker –

    Discreet packaging and fast arrival. Very happy with the product quality.

  18. Benjamin Reed –

    Easy website and secure checkout. Peptides were high quality and well packed.

  19. Lily Morgan –

    Impressive purity and professional packaging. Highly recommend Peptides Unit.

  20. Henry Foster –

    Fast shipping and excellent customer service. Will definitely reorder.

  21. Zoe Mitchell –

    Reliable vendor with good pricing. Product arrived quickly and as described.

  22. Samuel Turner –

    Great communication and top-notch peptides. Very satisfied with my order.

  23. Nora Phillips –

    Secure packaging and fast delivery. Product quality exceeded expectations.

Add a review

23 reviews for Retatrutide

  1. Ava Thompson –

    Fast shipping and excellent peptide quality. Packaging was discreet and professional.

  2. Liam Carter –

    Product arrived quickly and purity matched the COA. Very reliable vendor.

  3. Sophia Nguyen –

    Good quality peptides and easy ordering process. Shipping was prompt.

  4. Noah Bennett –

    Great customer service and fast delivery. Product worked exactly as expected.

  5. Mia Rodriguez –

    Secure checkout and sterile packaging. I was impressed with the quality.

  6. Ethan Walker –

    Competitive pricing and reliable products. Delivery took a few days but was smooth.

  7. Isabella Kim –

    Excellent purity and professional service. Will definitely order again.

  8. Mason Clark –

    Batch-specific COA included and product quality was top-notch. Highly recommend.

  9. Amelia Davis –

    Good experience overall. Peptides were as described and shipping was quick.

  10. Lucas Martinez –

    Fast and discreet shipping. Product integrity was perfect and support was helpful.

  11. Harper Lewis –

    Very satisfied with the quality and speed of delivery. Trustworthy supplier.

  12. Oliver Young –

    Solid vendor with fair prices. Products arrived well packaged and on time.

  13. Evelyn Hall –

    Excellent customer support and high-quality peptides. Five stars.

  14. Elijah Allen –

    Smooth ordering and quick delivery. Purity was exactly as stated.

  15. Chloe Wright –

    Good quality and responsive support. Shipping was slightly delayed but resolved.

  16. James Scott –

    Reliable source with great COAs. Product worked perfectly in my research.

  17. Grace Baker –

    Discreet packaging and fast arrival. Very happy with the product quality.

  18. Benjamin Reed –

    Easy website and secure checkout. Peptides were high quality and well packed.

  19. Lily Morgan –

    Impressive purity and professional packaging. Highly recommend Peptides Unit.

  20. Henry Foster –

    Fast shipping and excellent customer service. Will definitely reorder.

  21. Zoe Mitchell –

    Reliable vendor with good pricing. Product arrived quickly and as described.

  22. Samuel Turner –

    Great communication and top-notch peptides. Very satisfied with my order.

  23. Nora Phillips –

    Secure packaging and fast delivery. Product quality exceeded expectations.

Add a review

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