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cjc 1295 with dac

CJC 1295 with DAC

Price range: $80.00 through $190.00

CJC 1295 with DAC (DAC:GRF) — Research Grade Peptide

  • Long-acting GHRH analog with albumin-binding DAC moiety

  • Half-life 5.8–8.1 days (vs ~30 min for no-DAC)

  • ≥98% purity (HPLC), MS-confirmed identity

  • Lyophilized powder · CAS 446262-90-4 · C₁₆₅H₂₆₉N₄₇O₄₆

  • Lot-specific COA included

  • For research use only 

99%+
Purity grade
24h
Dispatch
3rd
Party tested
Certificate of Analysis
Included with every batch
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Product Details

CJC 1295 with DAC (DAC:GRF) — Research Grade Peptide, ≥98% Purity (HPLC)

Long-acting GHRH analog. Lyophilized powder. Lot-specific COA included.

CJC 1295 with DAC, also known as DAC:GRF (Drug Affinity Complex:Growth Hormone-Releasing Factor), is a synthetic peptide analog of growth hormone-releasing hormone (GHRH) modified with a maleimidopropionic acid (MPA) linker that covalently binds to serum albumin following administration. This albumin conjugation is the defining feature of the DAC version: it extends the peptide’s half-life to approximately 5.8–8.1 days, compared with the roughly 30-minute half-life of the no-DAC form.

The peptide sequence is identical to Modified GRF 1-29 (four substitutions relative to native GHRH: D-Ala at position 2, Gln at position 8, Ala at position 15, and Leu at position 27), but the addition of the DAC moiety changes the pharmacokinetic profile fundamentally. A single administration produces sustained elevation of plasma growth hormone and IGF-1 rather than the discrete pulses produced by the no-DAC variant.

Supplied as a sterile-filtered, lyophilized powder for in vitro and preclinical research applications. Each lot is independently verified for purity and identity and ships with a Certificate of Analysis.

Specifications

Parameter Detail
CAS Number 446262-90-4
Molecular Formula C₁₆₅H₂₆₉N₄₇O₄₆
Molecular Weight 3647.19 g/mol (free base)
Sequence H-Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys(MPA)-OH
Purity ≥98% (HPLC)
Identity Confirmed by mass spectrometry
Appearance White to off-white lyophilized powder
Solubility Soluble in water and aqueous buffers
Storage −20 °C, desiccated, protected from light
Format Lyophilized powder, sterile-filtered
Documentation Lot-specific COA (HPLC + MS)

Note: CJC 1295 with DAC and CJC-1295 without DAC share the same CAS number (446262-90-4) in many catalogs, and the two molecules cannot be distinguished by CAS number alone. The critical differentiator is molecular weight: the DAC version is 3647.19 g/mol, while the no-DAC version is 3367.9 g/mol. Verify the molecular weight on your COA matches 3647.19 g/mol before accepting the lot. Suppliers also list a trifluoroacetate (TFA) salt form with the same formula and a molecular weight around 3401 g/mol; confirm the salt form against your COA. CJC 1295 with DAC

Research applications

CJC 1295 with DAC is used in laboratory settings to investigate:

  • Sustained GHRH receptor activation — albumin-conjugated peptide producing prolonged elevation of growth hormone and IGF-1 in preclinical models, with a half-life of 5.8–8.1 days

  • Growth hormone and IGF-1 pharmacokinetics — comparative study of pulsatile (no-DAC) versus sustained (DAC) GHRH analog administration in animal models

  • Albumin-binding peptide engineering — the maleimidopropionic acid linker as a model for extending peptide half-life through covalent albumin conjugation

  • Analytical method development — LC-MS/MS differentiation of CJC-1295 with and without DAC, a known challenge in peptide quality control given the shared CAS number

  • Comparative GHRH analog studies — head-to-head pharmacokinetic comparison with native GRF(1-29), sermorelin, and tesamorelin in preclinical models

Handling and storage

Reconstitute under aseptic conditions using sterile water or an appropriate aqueous buffer. CJC 1295 with DAC is soluble in water. Aliquot immediately after reconstitution to avoid repeated freeze-thaw cycles. Lyophilized powder is stable for up to 2 years at −20 °C under sealed, desiccated, light-protected conditions. Reconstituted solutions should be stored at 2–8 °C and used within 14–21 days. Do not freeze reconstituted solution.

CJC 1295 with DAC For laboratory use by qualified personnel only.

23 reviews for CJC 1295 with DAC

  1. Ava Thompson –

    Fast shipping and excellent peptide quality. Packaging was discreet and professional.

  2. Liam Carter –

    Product arrived quickly and purity matched the COA. Very reliable vendor.

  3. Sophia Nguyen –

    Good quality peptides and easy ordering process. Shipping was prompt.

  4. Noah Bennett –

    Great customer service and fast delivery. Product worked exactly as expected.

  5. Mia Rodriguez –

    Secure checkout and sterile packaging. I was impressed with the quality.

  6. Ethan Walker –

    Competitive pricing and reliable products. Delivery took a few days but was smooth.

  7. Isabella Kim –

    Excellent purity and professional service. Will definitely order again.

  8. Mason Clark –

    Batch-specific COA included and product quality was top-notch. Highly recommend.

  9. Amelia Davis –

    Good experience overall. Peptides were as described and shipping was quick.

  10. Lucas Martinez –

    Fast and discreet shipping. Product integrity was perfect and support was helpful.

  11. Harper Lewis –

    Very satisfied with the quality and speed of delivery. Trustworthy supplier.

  12. Oliver Young –

    Solid vendor with fair prices. Products arrived well packaged and on time.

  13. Evelyn Hall –

    Excellent customer support and high-quality peptides. Five stars.

  14. Elijah Allen –

    Smooth ordering and quick delivery. Purity was exactly as stated.

  15. Chloe Wright –

    Good quality and responsive support. Shipping was slightly delayed but resolved.

  16. James Scott –

    Reliable source with great COAs. Product worked perfectly in my research.

  17. Grace Baker –

    Discreet packaging and fast arrival. Very happy with the product quality.

  18. Benjamin Reed –

    Easy website and secure checkout. Peptides were high quality and well packed.

  19. Lily Morgan –

    Impressive purity and professional packaging. Highly recommend Peptides Unit.

  20. Henry Foster –

    Fast shipping and excellent customer service. Will definitely reorder.

  21. Zoe Mitchell –

    Reliable vendor with good pricing. Product arrived quickly and as described.

  22. Samuel Turner –

    Great communication and top-notch peptides. Very satisfied with my order.

  23. Nora Phillips –

    Secure packaging and fast delivery. Product quality exceeded expectations.

Add a review

23 reviews for CJC 1295 with DAC

  1. Ava Thompson –

    Fast shipping and excellent peptide quality. Packaging was discreet and professional.

  2. Liam Carter –

    Product arrived quickly and purity matched the COA. Very reliable vendor.

  3. Sophia Nguyen –

    Good quality peptides and easy ordering process. Shipping was prompt.

  4. Noah Bennett –

    Great customer service and fast delivery. Product worked exactly as expected.

  5. Mia Rodriguez –

    Secure checkout and sterile packaging. I was impressed with the quality.

  6. Ethan Walker –

    Competitive pricing and reliable products. Delivery took a few days but was smooth.

  7. Isabella Kim –

    Excellent purity and professional service. Will definitely order again.

  8. Mason Clark –

    Batch-specific COA included and product quality was top-notch. Highly recommend.

  9. Amelia Davis –

    Good experience overall. Peptides were as described and shipping was quick.

  10. Lucas Martinez –

    Fast and discreet shipping. Product integrity was perfect and support was helpful.

  11. Harper Lewis –

    Very satisfied with the quality and speed of delivery. Trustworthy supplier.

  12. Oliver Young –

    Solid vendor with fair prices. Products arrived well packaged and on time.

  13. Evelyn Hall –

    Excellent customer support and high-quality peptides. Five stars.

  14. Elijah Allen –

    Smooth ordering and quick delivery. Purity was exactly as stated.

  15. Chloe Wright –

    Good quality and responsive support. Shipping was slightly delayed but resolved.

  16. James Scott –

    Reliable source with great COAs. Product worked perfectly in my research.

  17. Grace Baker –

    Discreet packaging and fast arrival. Very happy with the product quality.

  18. Benjamin Reed –

    Easy website and secure checkout. Peptides were high quality and well packed.

  19. Lily Morgan –

    Impressive purity and professional packaging. Highly recommend Peptides Unit.

  20. Henry Foster –

    Fast shipping and excellent customer service. Will definitely reorder.

  21. Zoe Mitchell –

    Reliable vendor with good pricing. Product arrived quickly and as described.

  22. Samuel Turner –

    Great communication and top-notch peptides. Very satisfied with my order.

  23. Nora Phillips –

    Secure packaging and fast delivery. Product quality exceeded expectations.

Add a review

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