CJC-1295 (No DAC)

Product Overview

CJC-1295 without DAC (also known as Modified GRF 1-29 or Mod GRF) is a synthetic 29-amino acid peptide analogue of Growth Hormone-Releasing Hormone (GHRH) . Unlike its counterpart containing a Drug Affinity Complex (DAC), this “no DAC” version features a lysine deletion at the C-terminus, resulting in a much shorter half-life .

The “no DAC” form is specifically designed to support research requiring a physiologic, pulsatile release pattern of growth hormone, closely mimicking the body’s natural secretory rhythm . This approach may be preferred in research models where sustained, continuous GH elevation is not desired . CJC-1295 without DAC

Mechanism of Action

CJC-1295 without DAC functions as a GHRH receptor agonist:

• Pituitary Binding: Binds to GHRH receptors on pituitary somatotroph cells 

• Pulsatile GH Release: Stimulates the release of growth hormone in a pulsatile manner that emulates natural secretion patterns 

• Short Duration: The absence of DAC yields an approximate half-life of 30 minutes, preserving physiologic GH pulsatility 

• Receptor Sensitivity: Shorter half-life may reduce risk of receptor desensitization 

Key Research Applications:

• Pulsatile growth hormone release dynamics

• GHRH receptor signaling and function studies

• Pituitary function and regulation research

• Synergistic research with GHRPs (e.g., Ipamorelin) 

Product Specifications

Quality Assurance

Every batch undergoes rigorous analytical testing to ensure maximum purity and research integrity:

Certificate of Analysis (COA) available upon request.

Storage & Reconstitution Guidelines

Storage Conditions:

• Lyophilized (Long-term): -20°C, protected from light and moisture 

• Lyophilized (Short-term): 2°C – 8°C (refrigerated)

• Reconstituted: 4°C for up to 7 days; aliquot for extended storage; avoid repeated freeze-thaw cycles

Reconstitution Protocol:

1. Allow vial to reach room temperature

2. Add sterile bacteriostatic water or 0.9% sodium chloride solution

3. Gently swirl (do not vortex) until fully dissolved

Note: Peptides are sensitive to formulation, process, and environmental conditions that may lead to aggregation and degradation. CJC-1295 without DAC

Research Background

CJC-1295 No DAC vs. With DAC

Research Context

CJC-1295 without DAC has been referenced in scientific literature since at least 2010 . It is often studied in combination with growth hormone secretagogues like Ipamorelin for research into synergistic effects on pulsatile GH release . CJC-1295 without DAC

Important Notice

⚠️ FOR RESEARCH USE ONLY

This product is not intended for human consumption, diagnostic use, therapeutic application, or clinical administration. CJC-1295 is a research chemical intended exclusively for in-vitro and laboratory research purposes .

• Not approved by the FDA for human use

• Not a dietary supplement, food additive, or pharmaceutical

• Intended solely for qualified researchers and scientific institutions

By purchasing this product, you confirm that you are a licensed researcher or laboratory professional and agree to use this compound in compliance with all applicable local, national, and international regulations.

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CJC-1295 (No DAC) Peptide 5mg – ≥99% Purity
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