HCG
Price range: $85.00 through $165.00
HCG (Human Chorionic Gonadotropin) — Research Grade Glycoprotein
-
Heterodimeric glycoprotein hormone (α and β subunits)
-
Luteinizing hormone/choriogonadotropin receptor (LHCGR) agonist
-
≥95% purity (HPLC), MS and immunoassay confirmed identity
-
Lyophilized powder · CAS 9002-61-3 · ~37.9 kDa
-
Lot-specific COA included
-
For research use only
Product Details
HCG (Human Chorionic Gonadotropin) — Research Grade Glycoprotein, ≥95% Purity (HPLC)
Heterodimeric glycoprotein hormone. Luteinizing hormone receptor agonist. Lyophilized powder. Lot-specific COA included.
Human chorionic gonadotropin (HCG) is a glycoprotein hormone produced by syncytiotrophoblast cells of the placenta during pregnancy. It is a heterodimer composed of two non-covalently associated subunits: an α-subunit that is structurally identical to the α-subunit of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and thyroid-stimulating hormone (TSH), and a β-subunit that confers receptor specificity and biological activity. The β-subunit contains a unique C-terminal extension with four serine-linked carbohydrate chains that are absent from LH, and these glycosylation differences are responsible for HCG’s extended half-life relative to LH.
HCG binds and activates the luteinizing hormone/choriogonadotropin receptor (LHCGR), a G-protein–coupled receptor expressed on gonadal tissues. Receptor activation triggers cAMP accumulation and downstream steroidogenic pathways. In research settings, HCG is used as a tool compound to study gonadotropin receptor signaling, steroidogenesis, and reproductive endocrinology in both in vitro and in vivo models.
Supplied as a sterile-filtered, lyophilized powder for in vitro and preclinical research applications. Each lot is independently verified for purity and identity and ships with a Certificate of Analysis.
Specifications
| Parameter | Detail |
|---|---|
| CAS Number | 9002-61-3 |
| Molecular Weight | ~37.9 kDa (with ~31% carbohydrate by weight) |
| Subunit Structure | Heterodimer (α and β subunits, non-covalently linked) |
| β-Subunit Molecular Weight | ~23 kDa |
| Carbohydrate Content | ~31% by weight |
| Purity | ≥95% (HPLC) |
| Identity | Confirmed by mass spectrometry and immunoassay |
| Appearance | White to off-white lyophilized powder |
| Solubility | Soluble in water and aqueous buffers |
| Storage | −20 °C, desiccated, protected from light |
| Format | Lyophilized powder, sterile-filtered |
| Documentation | Lot-specific COA (HPLC + MS) |
Note: HCG is produced by extraction from human pregnancy urine or by recombinant DNA technology. The purity and specific activity may vary by source. Suppliers list molecular weights ranging from approximately 36,700 to 39,500 Da depending on the glycosylation profile and measurement method. Verify the specific activity, purity, and molecular weight against the Certificate of Analysis supplied with your lot.
Research applications
HCG is used in laboratory settings to investigate:
-
LHCGR signaling and cAMP accumulation — activation of the luteinizing hormone/choriogonadotropin receptor and downstream steroidogenic pathways in gonadal cell culture models
-
Steroidogenesis research — testosterone and progesterone production in Leydig cell and granulosa cell models, with HCG used as a standard agonist for LHCGR activation
-
Reproductive endocrinology — comparative study of HCG versus LH receptor binding and activation, and the role of glycosylation in hormone half-life and potency
-
Analytical method development — immunoassay calibration, LC-MS/MS quantification, and reference standard preparation for HCG analysis in biological matrices
-
Doping control research — development of dried blood spot (DBS) extraction protocols and nanoLC-MS/MS methods for detecting exogenous HCG in athletes
-
Gynecological research — HCG-secreting cell models and gestational trophoblastic disease research
Handling and storage
Reconstitute under aseptic conditions using sterile water or an appropriate aqueous buffer. HCG is soluble in water. Aliquot immediately after reconstitution to avoid repeated freeze-thaw cycles. Lyophilized powder is stable for up to 2 years at −20 °C under sealed, desiccated, light-protected conditions. Reconstituted solutions should be stored at 2–8 °C and used within 14–21 days. Do not freeze reconstituted solution.
For laboratory use by qualified personnel only.
23 reviews for HCG
Add a review
23 reviews for HCG
-
Fast shipping and excellent peptide quality. Packaging was discreet and professional.
-
Product arrived quickly and purity matched the COA. Very reliable vendor.
-
Good quality peptides and easy ordering process. Shipping was prompt.
-
Great customer service and fast delivery. Product worked exactly as expected.
-
Secure checkout and sterile packaging. I was impressed with the quality.
-
Competitive pricing and reliable products. Delivery took a few days but was smooth.
-
Excellent purity and professional service. Will definitely order again.
-
Batch-specific COA included and product quality was top-notch. Highly recommend.
-
Good experience overall. Peptides were as described and shipping was quick.
-
Fast and discreet shipping. Product integrity was perfect and support was helpful.
-
Very satisfied with the quality and speed of delivery. Trustworthy supplier.
-
Solid vendor with fair prices. Products arrived well packaged and on time.
-
Excellent customer support and high-quality peptides. Five stars.
-
Smooth ordering and quick delivery. Purity was exactly as stated.
-
Good quality and responsive support. Shipping was slightly delayed but resolved.
-
Reliable source with great COAs. Product worked perfectly in my research.
-
Discreet packaging and fast arrival. Very happy with the product quality.
-
Easy website and secure checkout. Peptides were high quality and well packed.
-
Impressive purity and professional packaging. Highly recommend Peptides Unit.
-
Fast shipping and excellent customer service. Will definitely reorder.
-
Reliable vendor with good pricing. Product arrived quickly and as described.
-
Great communication and top-notch peptides. Very satisfied with my order.
-
Secure packaging and fast delivery. Product quality exceeded expectations.
Ava Thompson –
Fast shipping and excellent peptide quality. Packaging was discreet and professional.
Liam Carter –
Product arrived quickly and purity matched the COA. Very reliable vendor.
Sophia Nguyen –
Good quality peptides and easy ordering process. Shipping was prompt.
Noah Bennett –
Great customer service and fast delivery. Product worked exactly as expected.
Mia Rodriguez –
Secure checkout and sterile packaging. I was impressed with the quality.
Ethan Walker –
Competitive pricing and reliable products. Delivery took a few days but was smooth.
Isabella Kim –
Excellent purity and professional service. Will definitely order again.
Mason Clark –
Batch-specific COA included and product quality was top-notch. Highly recommend.
Amelia Davis –
Good experience overall. Peptides were as described and shipping was quick.
Lucas Martinez –
Fast and discreet shipping. Product integrity was perfect and support was helpful.
Harper Lewis –
Very satisfied with the quality and speed of delivery. Trustworthy supplier.
Oliver Young –
Solid vendor with fair prices. Products arrived well packaged and on time.
Evelyn Hall –
Excellent customer support and high-quality peptides. Five stars.
Elijah Allen –
Smooth ordering and quick delivery. Purity was exactly as stated.
Chloe Wright –
Good quality and responsive support. Shipping was slightly delayed but resolved.
James Scott –
Reliable source with great COAs. Product worked perfectly in my research.
Grace Baker –
Discreet packaging and fast arrival. Very happy with the product quality.
Benjamin Reed –
Easy website and secure checkout. Peptides were high quality and well packed.
Lily Morgan –
Impressive purity and professional packaging. Highly recommend Peptides Unit.
Henry Foster –
Fast shipping and excellent customer service. Will definitely reorder.
Zoe Mitchell –
Reliable vendor with good pricing. Product arrived quickly and as described.
Samuel Turner –
Great communication and top-notch peptides. Very satisfied with my order.
Nora Phillips –
Secure packaging and fast delivery. Product quality exceeded expectations.