HMG Menotropins
$68.00
HMG (Human Menopausal Gonadotropin, Menotropins) — Research Grade Glycoprotein
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Purified gonadotropin preparation with FSH and LH activity (~1:1 ratio)
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Not a peptide — glycoprotein hormone biologic
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≥95% purity (HPLC), MS and immunoassay confirmed identity
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Lyophilized powder · CAS 9002-68-0 · ~23,390 g/mol
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Lot-specific COA included
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For research use only
Product Details
HMG (Human Menopausal Gonadotropin, Menotropins) — Research Grade Glycoprotein, ≥95% Purity (HPLC)
Dual FSH/LH gonadotropin preparation. Lyophilized powder. Lot-specific COA included.
HMG (human menopausal gonadotropin), also known by its generic name menotropins, is a purified gonadotropin preparation extracted from the urine of postmenopausal women. It contains both follicle-stimulating hormone (FSH) and luteinizing hormone (LH) activity in an approximately 1:1 ratio, with chorionic gonadotropin (hCG) added as needed for standardization. The USP monograph specifies a potency of not less than 40 USP FSH Units and not less than 40 USP LH Units per mg, with not more than 30% of LH activity contributed by added chorionic gonadotropin.
HMG is not a peptide. It is a biologic — a glycoprotein hormone preparation with a molar mass of approximately 23,390 g/mol and an empirical formula of C₁₀₁₄H₁₆₀₉N₂₈₇O₂₉₄S₂₇. Highly purified menotropin (HP-hMG), marketed as Menopur, represents an advanced purified formulation with reduced protein impurities.
Supplied as a sterile-filtered, lyophilized powder for in vitro and preclinical research applications. Each lot is independently verified for purity and identity and ships with a Certificate of Analysis.
Specifications
| Parameter | Detail |
|---|---|
| CAS Number | 9002-68-0; 61489-71-2 |
| UNII Code | 5Y9QQM372Q |
| Empirical Formula | C₁₀₁₄H₁₆₀₉N₂₈₇O₂₉₄S₂₇ |
| Molecular Weight | ~23,390 g/mol |
| Composition | FSH and LH activity, ~1:1 ratio |
| FSH Structure | α-subunit 92 residues; β-subunit 111 residues |
| LH Structure | α-subunit 92 residues; β-subunit 121 residues |
| Purity | ≥95% (HPLC) |
| Identity | Confirmed by mass spectrometry and immunoassay |
| Appearance | White to off-white lyophilized powder |
| Solubility | Soluble in water and aqueous buffers |
| Storage | −20 °C, desiccated, protected from light |
| Format | Lyophilized powder, sterile-filtered |
| Documentation | Lot-specific COA (HPLC + MS) |
Note: HMG is a urinary-derived product. The purity and specific activity may vary by source and purification method. Suppliers list molecular weights ranging from approximately 23,000 to 40,000 Da depending on the glycosylation profile and measurement method. Verify the specific activity, purity, and FSH:LH ratio against the Certificate of Analysis supplied with your lot.
Research applications
HMG is used in laboratory settings to investigate:
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Gonadotropin receptor signaling — dual activation of FSH receptor (FSHR) and LH/choriogonadotropin receptor (LHCGR) and downstream cAMP accumulation in gonadal cell culture models
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Follicular development and oocyte maturation — FSH-mediated granulosa cell proliferation and estrogen production in ovarian tissue models
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Spermatogenesis research — combined FSH and LH activity in Sertoli and Leydig cell co-culture systems, and comparative study with recombinant FSH
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Comparative gonadotropin pharmacology — head-to-head comparison of urinary-derived HMG versus recombinant FSH (rFSH) for receptor binding affinity, potency, and downstream signaling
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Analytical method development — immunoassay calibration, LC-MS/MS quantification, and reference standard preparation for gonadotropin analysis in biological matrices
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Ovarian hyperstimulation syndrome (OHSS) research — mechanistic study of vascular endothelial growth factor (VEGF) and other mediators implicated in OHSS pathogenesis
Handling and storage
Reconstitute under aseptic conditions using sterile water or the diluent supplied with the product. HMG is soluble in water. Aliquot immediately after reconstitution to avoid repeated freeze-thaw cycles. Lyophilized powder is stable for up to 2 years at −20 °C under sealed, desiccated, light-protected conditions. Reconstituted solutions should be stored at 2–8 °C and used within 14–21 days. Do not freeze reconstituted solution.
For laboratory use by qualified personnel only.
23 reviews for HMG Menotropins
Add a review
23 reviews for HMG Menotropins
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Fast shipping and excellent peptide quality. Packaging was discreet and professional.
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Product arrived quickly and purity matched the COA. Very reliable vendor.
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Good quality peptides and easy ordering process. Shipping was prompt.
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Great customer service and fast delivery. Product worked exactly as expected.
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Secure checkout and sterile packaging. I was impressed with the quality.
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Competitive pricing and reliable products. Delivery took a few days but was smooth.
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Excellent purity and professional service. Will definitely order again.
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Batch-specific COA included and product quality was top-notch. Highly recommend.
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Good experience overall. Peptides were as described and shipping was quick.
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Fast and discreet shipping. Product integrity was perfect and support was helpful.
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Very satisfied with the quality and speed of delivery. Trustworthy supplier.
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Solid vendor with fair prices. Products arrived well packaged and on time.
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Excellent customer support and high-quality peptides. Five stars.
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Smooth ordering and quick delivery. Purity was exactly as stated.
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Good quality and responsive support. Shipping was slightly delayed but resolved.
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Reliable source with great COAs. Product worked perfectly in my research.
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Discreet packaging and fast arrival. Very happy with the product quality.
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Easy website and secure checkout. Peptides were high quality and well packed.
-
Impressive purity and professional packaging. Highly recommend Peptides Unit.
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Fast shipping and excellent customer service. Will definitely reorder.
-
Reliable vendor with good pricing. Product arrived quickly and as described.
-
Great communication and top-notch peptides. Very satisfied with my order.
-
Secure packaging and fast delivery. Product quality exceeded expectations.
Add a review
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Ethan Walker –
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Isabella Kim –
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Mason Clark –
Batch-specific COA included and product quality was top-notch. Highly recommend.
Amelia Davis –
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Lucas Martinez –
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Harper Lewis –
Very satisfied with the quality and speed of delivery. Trustworthy supplier.
Oliver Young –
Solid vendor with fair prices. Products arrived well packaged and on time.
Evelyn Hall –
Excellent customer support and high-quality peptides. Five stars.
Elijah Allen –
Smooth ordering and quick delivery. Purity was exactly as stated.
Chloe Wright –
Good quality and responsive support. Shipping was slightly delayed but resolved.
James Scott –
Reliable source with great COAs. Product worked perfectly in my research.
Grace Baker –
Discreet packaging and fast arrival. Very happy with the product quality.
Benjamin Reed –
Easy website and secure checkout. Peptides were high quality and well packed.
Lily Morgan –
Impressive purity and professional packaging. Highly recommend Peptides Unit.
Henry Foster –
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Zoe Mitchell –
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Samuel Turner –
Great communication and top-notch peptides. Very satisfied with my order.
Nora Phillips –
Secure packaging and fast delivery. Product quality exceeded expectations.