Mazdutide
$195.00
Mazdutide (IBI362, LY3305677) — Research Grade Peptide
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Dual GLP-1/glucagon receptor agonist (modelled on oxyntomodulin)
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≥98% purity (HPLC), MS-confirmed identity
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Lyophilized powder · CAS 2259884-03-0 · C₂₁₀H₃₂₂N₄₆O₆₇
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Lot-specific COA included
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For research use only
Product Details
Mazdutide Peptide (IBI362, LY3305677) — Research Grade Peptide, ≥98% Purity (HPLC)
Dual GLP-1/glucagon receptor agonist. Lyophilized powder. Lot-specific COA included.
Mazdutide Peptide, also known as IBI362 or LY3305677, is a synthetic 29-amino acid peptide engineered as a dual agonist at the glucagon-like peptide-1 (GLP-1) receptor and the glucagon (GCG) receptor. The compound is modelled on the endogenous peptide hormone oxyntomodulin, a naturally occurring dual agonist that activates both receptors. Its extended half-life is achieved through a C20 fatty diacid moiety conjugated via a linker to the lysine residue at position 20, promoting albumin binding and once-weekly dosing in preclinical models.
The dual mechanism distinguishes Mazdutide Peptide from selective GLP-1 receptor agonists. GLP-1R activation mediates insulin secretion, appetite suppression, and gastric emptying, while GCGR activation increases energy expenditure and hepatic fatty acid oxidation. The hypothesised therapeutic advantage of this dual approach is preferential loss of adipose tissue rather than lean mass. In cell culture, mazdutide stimulates adenylyl cyclase activity via both GCGR and GLP-1R.
Supplied as a sterile-filtered, lyophilized powder for in vitro and preclinical research applications. Each lot is independently verified for purity and identity and ships with a Certificate of Analysis.
Specifications
| Parameter | Detail |
|---|---|
| CAS Number | 2259884-03-0 |
| Molecular Formula | C₂₁₀H₃₂₂N₄₆O₆₇ |
| Molecular Weight | 4563.06 g/mol (free base) |
| Sequence | H-His-Aib-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Glu-Lys-Lys-Ala-Lys(AEEA-AEEA-γGlu-nonadecanoic acid)-Glu-Phe-Val-Glu-Trp-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-NH₂ |
| Purity | ≥98% (HPLC) |
| Identity | Confirmed by mass spectrometry |
| Appearance | White to off-white lyophilized powder |
| Solubility | Soluble in water and aqueous buffers |
| Storage | −20 °C, desiccated, protected from light |
| Format | Lyophilized powder, sterile-filtered |
| Documentation | Lot-specific COA (HPLC + MS) |
Note: Mazdutide Peptide is supplied in both free base and trifluoroacetate (TFA) salt forms. Verify the exact form, molecular weight, and purity against the Certificate of Analysis supplied with your lot.
Research applications
Mazdutide Peptide is used in laboratory settings to investigate:
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Dual incretin receptor signaling — simultaneous activation of GLP-1R and GCGR, and downstream cAMP accumulation via adenylyl cyclase in transfected cell lines
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Hepatic lipid metabolism and MAFLD/MASH research — suppression of lipid uptake, de novo lipogenesis, and lipid droplet formation, primarily through modulation of the PPAR signaling pathway
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Diabetes-associated cognitive dysfunction — mechanistic studies involving downregulation of VGlut2 expression and modulation of NMDA/GABA receptor crosstalk
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Cardiac inotropy studies — increased contractile force in isolated human atrial preparations, with adenylyl cyclase stimulation via both GCGR and GLP-1R
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Energy expenditure and adipose tissue research — GCGR-mediated lipolysis and thermogenesis in diet-induced obese (DIO) mouse models
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Analytical method development — LC-MS/MS quantification and reference standard preparation for dual agonist peptide analysis
Handling and storage
Reconstitute under aseptic conditions using sterile water or an appropriate aqueous buffer. Mazdutide is soluble in water. Aliquot immediately after reconstitution to avoid repeated freeze-thaw cycles. Lyophilized powder is stable for up to 2 years at −20 °C under sealed, desiccated, light-protected conditions. Reconstituted solutions should be stored at 2–8 °C and used within 14–21 days. Do not freeze reconstituted solution. Mazdutide Peptide
Mazdutide Peptide For laboratory use by qualified personnel only.
23 reviews for Mazdutide
Add a review
23 reviews for Mazdutide
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Fast shipping and excellent peptide quality. Packaging was discreet and professional.
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Product arrived quickly and purity matched the COA. Very reliable vendor.
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Good quality peptides and easy ordering process. Shipping was prompt.
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Great customer service and fast delivery. Product worked exactly as expected.
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Secure checkout and sterile packaging. I was impressed with the quality.
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Competitive pricing and reliable products. Delivery took a few days but was smooth.
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Excellent purity and professional service. Will definitely order again.
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Batch-specific COA included and product quality was top-notch. Highly recommend.
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Good experience overall. Peptides were as described and shipping was quick.
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Fast and discreet shipping. Product integrity was perfect and support was helpful.
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Very satisfied with the quality and speed of delivery. Trustworthy supplier.
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Solid vendor with fair prices. Products arrived well packaged and on time.
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Excellent customer support and high-quality peptides. Five stars.
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Smooth ordering and quick delivery. Purity was exactly as stated.
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Good quality and responsive support. Shipping was slightly delayed but resolved.
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Reliable source with great COAs. Product worked perfectly in my research.
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Discreet packaging and fast arrival. Very happy with the product quality.
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Easy website and secure checkout. Peptides were high quality and well packed.
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Impressive purity and professional packaging. Highly recommend Peptides Unit.
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Fast shipping and excellent customer service. Will definitely reorder.
-
Reliable vendor with good pricing. Product arrived quickly and as described.
-
Great communication and top-notch peptides. Very satisfied with my order.
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Secure packaging and fast delivery. Product quality exceeded expectations.
Add a review
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Ava Thompson –
Fast shipping and excellent peptide quality. Packaging was discreet and professional.
Liam Carter –
Product arrived quickly and purity matched the COA. Very reliable vendor.
Sophia Nguyen –
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Noah Bennett –
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Mia Rodriguez –
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Ethan Walker –
Competitive pricing and reliable products. Delivery took a few days but was smooth.
Isabella Kim –
Excellent purity and professional service. Will definitely order again.
Mason Clark –
Batch-specific COA included and product quality was top-notch. Highly recommend.
Amelia Davis –
Good experience overall. Peptides were as described and shipping was quick.
Lucas Martinez –
Fast and discreet shipping. Product integrity was perfect and support was helpful.
Harper Lewis –
Very satisfied with the quality and speed of delivery. Trustworthy supplier.
Oliver Young –
Solid vendor with fair prices. Products arrived well packaged and on time.
Evelyn Hall –
Excellent customer support and high-quality peptides. Five stars.
Elijah Allen –
Smooth ordering and quick delivery. Purity was exactly as stated.
Chloe Wright –
Good quality and responsive support. Shipping was slightly delayed but resolved.
James Scott –
Reliable source with great COAs. Product worked perfectly in my research.
Grace Baker –
Discreet packaging and fast arrival. Very happy with the product quality.
Benjamin Reed –
Easy website and secure checkout. Peptides were high quality and well packed.
Lily Morgan –
Impressive purity and professional packaging. Highly recommend Peptides Unit.
Henry Foster –
Fast shipping and excellent customer service. Will definitely reorder.
Zoe Mitchell –
Reliable vendor with good pricing. Product arrived quickly and as described.
Samuel Turner –
Great communication and top-notch peptides. Very satisfied with my order.
Nora Phillips –
Secure packaging and fast delivery. Product quality exceeded expectations.