MOTS-C

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino acid peptide encoded by a short open reading frame (sORF) within the mitochondrial 12S ribosomal RNA (rRNA) gene . It belongs to a newly discovered class of mitochondrial-derived peptides (MDPs), which includes humanin and six small humanin-like peptides (SHLP1-6) .

Unlike proteins encoded by nuclear DNA, MOTS-c is translated in the cytoplasm after its polyadenylated transcript is exported from the mitochondria, using the standard genetic code . This peptide is highly conserved across species, detectable in various tissues and in circulation, and its expression declines with age .

In preclinical research models, MOTS-c has been investigated for its role in metabolic regulation through activation of the AMPK (AMP-activated protein kinase) pathway, making it a compound of significant interest in metabolic, aging, and mitochondrial research .

Mechanism of Action

MOTS-c functions through a distinct intracellular signaling mechanism :

• AMPK Pathway Activation: The primary cellular action of MOTS-c involves targeting the folate-methionine cycle and its tethered de novo purine biosynthesis pathway. This interaction leads to the accumulation of the metabolic intermediate AICAR, which subsequently activates AMPK .

• Metabolic Regulation: Through AMPK activation, MOTS-c modulates cellular metabolism, including glucose utilization and fatty acid metabolism .

• Stress Response & Inflammation: Research demonstrates MOTS-c exerts anti-inflammatory effects by inhibiting MAP kinase pathways (ERK, JNK, P38) and the c-fos signaling pathway .

• Nuclear Gene Regulation: MOTS-c can translocate to the nucleus to regulate nuclear gene expression in response to metabolic stress .

Key Research Applications:

• Metabolic homeostasis and insulin sensitivity studies 

• Mitochondrial function and aging research 

• AMPK signaling pathway investigations 

• Muscle health and atrophy research 

• Inflammation and stress response models 

Product Specifications

Quality Assurance

Every batch of MOTS-C undergoes rigorous analytical testing to ensure maximum purity and research integrity:

Certificate of Analysis (COA) available upon request.

Storage & Reconstitution Guidelines

Storage Conditions:

• Lyophilized (Long-term): -20°C, protected from light and moisture 

• Lyophilized (Short-term): 2°C – 8°C (refrigerated) 

• Reconstituted: 4°C for up to 7 days; aliquot and store at -20°C for longer storage; avoid repeated freeze-thaw cycles 

Reconstitution Protocol:

1. Allow vial to reach room temperature

2. Add sterile bacteriostatic water or 0.9% sodium chloride solution

3. Gently swirl (do not vortex) until fully dissolved

4. Allow solution to stand at 4°C for complete reconstitution

Note: Peptides are sensitive to formulation, process, and environmental conditions that may lead to aggregation and degradation.

Research Background

Discovery & Significance

MOTS-c was identified as a signaling peptide encoded by a short open reading frame (sORF) within the mitochondrial 12S rRNA gene . It is distinct from other mitochondrial-derived peptides, and unlike nuclear-encoded proteins, its transcript is exported from mitochondria before translation . MOTS-c is highly conserved across species .

Preclinical Research

Preclinical research has investigated MOTS-c in several areas :

Important Notice

⚠️ FOR RESEARCH USE ONLY

This product is not intended for human consumption, diagnostic use, therapeutic application, or clinical administration. MOTS-C is a research chemical intended exclusively for in-vitro and laboratory research purposes.

• Not approved by the FDA for human use

• Not a dietary supplement, food additive, or pharmaceutical

• No sales to individuals; intended solely for qualified researchers and scientific institutions 

• Use as intended only

By purchasing this product, you confirm that you are a licensed researcher or laboratory professional and agree to use this compound in compliance with all applicable local, national, and international regulations.

Why Choose PeptidesUnit.com?

Order Now

MOTS-C Peptide 5mg – ≥99% Purity
Available for immediate shipment

🛒 BUY NOW at PeptidesUnit.com