GHK-Cu (Copper Tripeptide) – Research Grade

GHK-Cu peptide (glycyl-L-histidyl-L-lysine-copper) is a naturally occurring copper-binding tripeptide first identified and developed by Loren Pickart in 1973 . Found in human plasma, saliva, and urine, GHK-Cu peptide plays a central role in tissue repair, acting as both a signal peptide and a carrier peptide for copper ions . The complex combines the tripeptide GHK with a copper (II) ion, forming a stable chelate that delivers copper to target tissues .

As one of the most extensively studied copper peptides, GHK-Cu is valued in research for its ability to promote extracellular matrix remodeling, stimulate collagen and elastin synthesis, and exert potent anti-inflammatory and antioxidant effects .

Mechanism of Action

GHK-Cu peptide functions through multiple biological pathways relevant to regenerative and cellular biology research:

• Collagen & Elastin Synthesis: Stimulates fibroblasts to increase messenger RNA production for collagen, elastin, proteoglycans, and glycosaminoglycans . Type I and IV collagen production is enhanced .

• Angiogenesis & Wound Healing: Promotes new blood vessel formation by upregulating VEGF, FGF-2, and other angiogenic factors . Accelerates wound closure and tissue repair in research models .

• Cellular Signaling: Functions as a chemical attractant for inflammatory and endothelial cells during wound healing . Activates copper chaperones (CCS, Atox1) that translocate to the nucleus to act as transcription factors .

• Antioxidant & Anti-inflammatory: Suppresses pro-inflammatory cytokines (TNF-β, IL-6) through inhibition of NF-κB and p38 MAPK pathways . Scavenges toxic lipid peroxidation products and reduces reactive oxygen species .

Key Research Applications:

• Skin regeneration and wound healing studies 

• Collagen and elastin synthesis investigations 

• Angiogenesis and vascular research 

• Bone regeneration and osteogenic research 

• Age-related cognitive decline studies 

Product Specifications

Quality Assurance

Every batch of GHK-Cu peptide undergoes rigorous analytical testing to ensure maximum purity and research integrity:

Certificate of Analysis (COA) available upon request.

Research Background

Discovery & Historical Significance

GHK-Cu peptide was discovered by Loren Pickart in 1973, who observed that plasma from younger donors promoted superior tissue repair compared to older donors . Plasma concentrations of GHK average about 200 ng/mL at age 20 but decline to approximately 80 ng/mL by age 60, reflecting the body’s decreased regenerative capacity over time .

Key Research Findings

Neuroprotective Research

Recent research (2025) demonstrates that GHK-Cu peptide improves hippocampal-dependent learning in aged mice through distinct biological modes. Intranasal administration induced coordinated suppression of oxidative phosphorylation and MYC target pathways, while intraperitoneal treatment activated DNA repair and stress-response pathways .

Formulation & Delivery Considerations

For research applications, skin permeability is a key consideration. Studies show that GHK-Cu peptide combined with hyaluronic acid (HA) produces synergistic collagen expression, enhancing collagen IV production by up to 25-fold in cell models . Microneedle-mediated delivery has demonstrated significantly enhanced dermal penetration, transporting up to 705 nanomoles of copper across treated skin .

Storage & Reconstitution Guidelines

Storage Conditions:

• Lyophilized (Long-term): -20°C or -80°C, protected from light, dry, sealed 

• Lyophilized (Short-term): 2°C – 8°C (refrigerated)

• Reconstituted: 4°C for up to 7 days; aliquot for extended storage; avoid repeated freeze-thaw cycles 

Reconstitution Protocol:

1. Allow vial to reach room temperature

2. Add sterile bacteriostatic water or 0.9% sodium chloride solution

3. Gently swirl (do not vortex) until fully dissolved

4. Aliquot for extended storage to minimize freeze-thaw degradation

Note: Peptides are sensitive to formulation, process, and environmental conditions that may lead to aggregation and degradation.

Important Notice

⚠️ FOR RESEARCH USE ONLY

This product is not intended for human consumption, diagnostic use, therapeutic application, or clinical administration. GHK-Cu peptide is a research chemical intended exclusively for in-vitro and laboratory research purposes .

• Not approved by the FDA for human use

• Not a dietary supplement, food additive, or pharmaceutical for over-the-counter purchase

• Intended solely for qualified researchers and scientific institutions

By purchasing this product, you confirm that you are a licensed researcher or laboratory professional and agree to use this compound in compliance with all applicable local, national, and international regulations.

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GHK-Cu (Copper Tripeptide) Peptide 5mg – ≥99% Purity
Available for immediate shipment ghk cu copper peptide

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