HCG Peptide (Human Chorionic Gonadotropin) – Research Grade

HCG Peptide (Human Chorionic Gonadotropin) is a naturally occurring peptide hormone composed of 244 amino acids arranged in two non-covalently linked subunits: a 92-amino acid alpha subunit and a 145-amino acid beta subunit . The alpha subunit shares homology with other hormones including LH, FSH, and TSH, while the beta subunit is unique to HCG Peptide and confers its specific biological activity .

HCG Peptide is produced by the syncytiotrophoblast (part of the placenta) shortly after conception and serves as the basis for early pregnancy detection . In research settings, HCG Peptide is extensively studied for its role in reproductive endocrinology, its ability to mimic luteinizing hormone (LH) by binding to ovarian LH receptors, and its unique structural characteristics as a glycoprotein hormone.

⚠️ Research Context: This product is intended exclusively for in-vitro and laboratory research purposes. It is not approved by the FDA for over-the-counter use as a weight loss agent, and its use for such purposes is not supported by substantial scientific evidence.

Mechanism of Action

HCG Peptide functions through the activation of LH receptors:

• LH Receptor Mimicry: HCG binds to ovarian LH receptors, mimicking the action of luteinizing hormone and triggering ovulation and progesterone production 

• Corpus Luteum Support: Maintains the corpus luteum during early pregnancy, ensuring continued progesterone production critical for pregnancy maintenance 

• Glycoprotein Structure: The complex carbohydrate moieties attached to both the alpha and beta subunits contribute to biological activity and metabolic stability 

Key Research Applications:

• Reproductive endocrinology and ovarian function studies

• Assisted reproductive technology (IVF) research models

• Glycoprotein hormone structure-function investigations

• LH receptor signaling pathway studies

Product Specifications

Quality Assurance

Every batch of HCG Peptide undergoes rigorous analytical testing to ensure maximum purity and research integrity :

Certificate of Analysis (COA) available upon request.

Research Background

Structural Characteristics

HCG Peptide is a heterodimeric glycoprotein with complex glycosylation patterns. The beta subunit contains O- and N-glycosylation sites at ASN-13, ASN-30, SER-121, SER-127, SER-132, and SER-138 . The alpha subunit has N-glycosylation sites at ASN-52 and ASN-78 . The glycoform pattern of recombinant hCG is closely comparable to urinary-derived hCG .

Immunological Research

Specific peptide regions of the beta chain (residues 109-119) have been identified as unique determinants of hCG that do not cross-react with homologous hormones like hLH . This has formed the basis for the development of hCG-specific antibodies .

Clinical Research Context

In clinical research, hCG is used as a surrogate for LH in IVF protocols, typically administered at doses of 5,000–10,000 IU . The circulating half-life of hCG is approximately 33.5 hours, making it suitable for inducing final oocyte maturation . Recombinant hCG (rhCG) is administered at doses of 250–500 μg .

Storage & Reconstitution Guidelines

Storage Conditions:

• Lyophilized (Long-term): -20°C, protected from light and moisture 

• Lyophilized (Short-term): 2°C – 8°C (refrigerated) 

• Reconstituted: 4°C for up to 7 days; aliquot and store at -20°C for longer storage 

Reconstitution Protocol:

1. Centrifuge vial briefly to bring contents to bottom

2. Add sterile water to achieve a concentration of at least 100 µg/mL 

3. Gently swirl (do not vortex) until fully dissolved

4. Aliquot for extended storage to avoid repeated freeze-thaw cycles 

Note: Peptides are sensitive to formulation and environmental conditions that may lead to aggregation and degradation.

Important Notice

⚠️ FOR RESEARCH USE ONLY

This product is not intended for human consumption, diagnostic use, therapeutic application, or clinical administration. HCG is a research chemical intended exclusively for in-vitro and laboratory research purposes.

• Not approved by the FDA for human use outside of prescription clinical settings

• Not a dietary supplement, food additive, or pharmaceutical for over-the-counter purchase

• Intended solely for qualified researchers and scientific institutions

By purchasing this product, you confirm that you are a licensed researcher or laboratory professional and agree to use this compound in compliance with all applicable local, national, and international regulations.

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HCG Peptide (Human Chorionic Gonadotropin) – ≥99% Purity
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