Mazdutide Peptide – Research Grade Dual GLP-1/Glucagon Receptor Agonist

Product Overview

Mazdutide (also known as IBI-362) is a synthetic long-acting peptide related to mammalian oxyntomodulin (OXM), modified with a fatty acid side chain to prolong its duration of action and allow once-weekly administration . It functions as a balanced dual agonist of the glucagon-like peptide-1 receptor (GLP-1R) and the glucagon receptor (GCGR) .

Mazdutide received its first approval in June 2025 in China for long-term body weight management in adults with obesity or overweight . In September 2025, it received additional approval in China for glycemic control in adults with type 2 diabetes .

⚠️ Research Context: This product is intended exclusively for in-vitro and laboratory research purposes.

Mechanism of Action

Mazdutide functions through a unique “dual metabolic engine” mechanism by activating both GLP-1 and glucagon receptors :

GLP-1 Receptor Activation:

• Suppresses appetite and slows gastric emptying 

• Enhances insulin secretion and improves glycemic control 

Glucagon Receptor Activation:

• Increases energy expenditure and basal metabolic rate 

• Promotes fatty acid oxidation and hepatic fat breakdown 

• Reduces liver fat accumulation 

Dual Synergy:

• The combination produces greater weight loss than GLP-1 monotherapy by reducing energy intake while increasing energy expenditure 

• Activates multiple signaling pathways including cAMP signaling (hsa04024) and insulin secretion pathways (hsa04911) 

Key Research Applications:

• Metabolic regulation and energy homeostasis studies

• Adipose tissue metabolism and hepatic steatosis research

• Glucose metabolism and insulin sensitivity investigations

• Cardiometabolic risk factor research

• GLP-1/glucagon receptor co-agonism pharmacology

Product Specifications

Research Background

Clinical Trial Evidence

Phase III GLORY-1 Trial Results :

Meta-Analysis Data :

• Weight Loss: Mean reduction of -12.42% body weight (95% CI: -16.15% to -8.68%) 

• Absolute Weight Loss: -9.76 kg (95% CI: -13.15 to -6.37 kg) 

• HbA1c Reduction: -0.63% (95% CI: -0.82 to -0.44) in T2DM patients 

• Systolic Blood Pressure: -7.68 mmHg reduction 

• LDL Cholesterol: -0.37 mmol/L reduction 

Liver Fat Reduction:

• Mazdutide 6mg demonstrated an 80.2% reduction in liver fat content in participants with elevated liver fat at baseline, compared to only 5.3% reduction with placebo .

Safety Profile

The most common adverse events are gastrointestinal side-effects, including nausea, vomiting, and diarrhea, which are typically mild to moderate and occur during dose escalation phases . Serious adverse events are rare, and discontinuation rates due to adverse events are low (1.5% for 4mg, 0.5% for 6mg, vs. 1% for placebo) .

Storage & Reconstitution Guidelines

Storage Conditions:

• Lyophilized (Long-term): -20°C (or -80°C for extended storage), protected from light, desiccated, inert gas charged 

• Lyophilized (Short-term): 2°C – 8°C (refrigerated)

• Reconstituted: 4°C for up to 7 days; aliquot for extended storage; avoid repeated freeze-thaw cycles

Reconstitution Protocol:

1. Allow vial to reach room temperature

2. Add sterile bacteriostatic water (ultrasonic and adjust pH to 2 with HCl may be needed for complete dissolution) 

3. Gently swirl (do not vortex) until fully dissolved

4. Dispense into individual aliquots to minimize freeze-thaw degradation

Note: Peptides are sensitive to formulation, process, and environmental conditions that may lead to aggregation and degradation.

Important Notice

⚠️ FOR RESEARCH USE ONLY

This product is not intended for human consumption, diagnostic use, therapeutic application, or clinical administration. Mazdutide is a research chemical intended exclusively for in-vitro and laboratory research purposes.

• Not a dietary supplement, food additive, or pharmaceutical for over-the-counter purchase

• Not approved by the FDA for human use outside of regulated prescription settings (approved in China for clinical use)

• Intended solely for qualified researchers and scientific institutions

By purchasing this product, you confirm that you are a licensed researcher or laboratory professional and agree to use this compound in compliance with all applicable local, national, and international regulations.

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Mazdutide Peptide 5mg – ≥99% Purity
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