HGH 191AA

Product Overview

HGH 191AA (Somatropin) is a recombinant human growth hormone (rhGH) consisting of 191 amino acids, identical in sequence to the dominant form of endogenous pituitary-derived growth hormone . Also known as somatotropin, this single-chain polypeptide is produced via recombinant DNA technology and serves as a critical reference material in endocrine research .

Somatropin was first approved by the FDA in 1976 and by the EMA in 2001, with biosimilar versions like Omnitrope® receiving EMA approval in 2006 . In research settings, HGH 191AA is studied for its role in growth regulation, IGF-1 signaling, metabolic pathways, and receptor binding kinetics .

Mechanism of Action

HGH 191AA functions as a peptide hormone that stimulates growth, cell reproduction, and regeneration . Its primary mechanism involves:

Growth Hormone Receptor Activation: Binds to growth hormone receptors (GHR) on target cells, initiating JAK-STAT signaling cascades

IGF-1 Mediated Signaling: Stimulates hepatic production of Insulin-like Growth Factor-1 (IGF-1), which mediates many anabolic effects 

Metabolic Regulation: Promotes lipolysis (fat breakdown) in adipose tissue and enhances protein synthesis in muscle 

Key Research Applications:

• Endocrine axis and growth hormone receptor studies

• IGF-1 signaling pathway research

• Metabolic regulation and body composition investigations

• Biomarker assay development and immunoassay validation

• Stability and degradation profiling under experimental conditions 

Product Specifications

Amino Acid Sequence (Full 191 AA):
FPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKYSFLQNPQTSLCFSESIPTPSNREETQQKSNLELLRISLLLIQSWLEPVQFLRSVFANSLVYGASDSNVYDLLKDLEEGIQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF 

Quality Assurance

Every batch of HGH 191AA undergoes comprehensive analytical testing to ensure maximum purity and research integrity:

Certificate of Analysis (COA) available upon request.

Storage & Reconstitution Guidelines

Storage Conditions:

• Lyophilized (Long-term): -20°C, protected from light and moisture 

• Lyophilized (Short-term): 2°C – 8°C (refrigerated)

• Reconstituted: 4°C for up to 1 month; -20°C for extended storage (aliquot to avoid freeze-thaw cycles) 

Reconstitution Protocol:

1. Briefly centrifuge vial to bring contents to bottom

2. Add sterile bacteriostatic water or 0.9% sodium chloride solution

3. Gently swirl (do not vortex) until fully dissolved 

4. Allow solution to stand for complete reconstitution

Note: Peptides are sensitive to formulation, process, and environmental conditions that may lead to aggregation and degradation.

Important Notice

⚠️ FOR RESEARCH USE ONLY

This product is not intended for human consumption, diagnostic use, therapeutic application, or clinical administration. HGH 191AA is a research chemical intended exclusively for in-vitro and laboratory research purposes .

• Not a dietary supplement, food additive, or pharmaceutical for over-the-counter purchase

• Requires prescription for clinical use; sold as research grade only

• Intended solely for qualified researchers and scientific institutions

By purchasing this product, you confirm that you are a licensed researcher or laboratory professional and agree to use this compound in compliance with all applicable local, national, and international regulations.

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HGH 191AA (Somatropin) Peptide – ≥99% Purity
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