Semax Peptide – Research Grade Nootropic

Product Overview

Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is a synthetic heptapeptide analog of the adrenocorticotropic hormone fragment ACTH(4-10) . Developed by Russian researchers in the 1980s, Semax was engineered to retain the neurotrophic and neuroprotective properties of ACTH while eliminating its hormonal (steroidogenic) activity . The peptide incorporates a unique C-terminal Pro-Gly-Pro motif that confers enhanced serum stability and metabolic resistance compared to the native ACTH fragment .

Semax is authorized for clinical use in Russia and Ukraine for indications including ischemic brain stroke, encephalopathy, optic nerve atrophy, and cognitive disorders such as dementia . Research continues to explore its potential in Alzheimer’s disease, traumatic brain injury (TBI), and other neurological conditions .

⚠️ Research Context: This product is intended exclusively for in-vitro and laboratory research purposes. It is not approved by the FDA for human use.

Mechanism of Action

Semax exerts its neuroprotective effects through multiple molecular pathways:

Neurotrophin Regulation:

• Enhances transcription of brain-derived neurotrophic factor (BDNF) and its receptors, supporting neuronal growth, survival, and synaptic plasticity 

• Demonstrates ~8-fold induction of BDNF mRNA in vitro 

Inflammation & Immune Modulation:

• Suppresses expression of inflammatory genes and modulates genes involved in immune response 

• Over 50% of genes with Semax-induced altered expression are related to immune system function 

• Downregulates pro-inflammatory mediators including MMP-9 and c-Fos in ischemic brain tissue 

Neurotransmitter Signaling:

• Modulates neurotransmitter gene expression and signaling pathways 

• Increases GABA-A receptor density by ~68% and reduces NMDA glycine site binding by ~66% in cortex 

• Regulates pJNK and pCREB activity; inhibits pJNK (cell death) while activating pCREB (neuroprotection and recovery) in ischemic models 

Vascular System Support:

• Alters expression of genes associated with endothelial tissue development, smooth muscle cell migration, hematopoiesis, and vasculogenesis 

Antioxidant & Anti-Amyloid Effects:

• Reduces oxidative stress and inflammation 

• Inhibits copper-induced Aβ aggregation and amyloid formation in research models 

Key Research Applications:

• Ischemic stroke and cerebral ischemia-reperfusion studies 

• Neurodegenerative disease research (Alzheimer’s, Parkinson’s) 

• Cognitive enhancement and memory studies 

• Neuroprotection and neurotrophic factor research

• Traumatic brain injury models 

Product Specifications

Quality Assurance

Every batch of Semax undergoes rigorous analytical testing to ensure maximum purity and research integrity:

Certificate of Analysis (COA) available upon request.

Research Background

Development History

Semax was developed by Russian researchers at the Institute of Molecular Genetics, Russian Academy of Sciences, in the 1980s and 1990s . The peptide was designed as a stabilized ACTH(4-10) fragment with enhanced stability and no hormonal side effects . The C-terminal Pro-Gly-Pro tripeptide was added to confer metabolic stability and prevent rapid proteolysis .

Key Research Findings

Ischemic Stroke Models:

• In a rat model of focal ischemia, Semax suppresses expression of inflammatory genes and activates neurotransmitter genes, contributing to neuroprotection 

• Genome-wide analysis revealed Semax-induced expression changes in over 50% of genes related to immune response 

• Immunomodulation and vascular system support are considered key neuroprotective mechanisms 

Cognitive Enhancement:

• BDNF upregulation supports synaptic plasticity and cognitive function 

• Research in animal models demonstrates improvements in learning and memory 

• Promising results in studies of attention deficit hyperactivity disorder (ADHD) 

Neurodegenerative Disease:

• Inhibits copper-induced Aβ aggregation and amyloid formation in model membranes 

• Demonstrates potential as anti-Alzheimer’s drug candidate 

Analgesic & Anxiolytic Effects:

• Demonstrates broadened dose-response profile for analgesia compared to ACTH(4-10) 

• Exhibits anxiolytic activity in rat models of maternal deprivation-induced anxiety 

Clinical Status

• Approved for clinical use in Russia and Ukraine for:

  • Ischemic brain stroke

  • Encephalopathy

  • Optic nerve atrophy

  • Cognitive disorders (dementia) 

• Not approved by the FDA for human use

• Research uses: Widely studied for neurodegenerative diseases and cognitive enhancement 

Storage & Reconstitution Guidelines

Storage Conditions:

• Lyophilized (Long-term): -20°C, protected from light, dry, sealed 

• Lyophilized (Short-term): 2°C – 8°C (refrigerated)

• Reconstituted: 4°C for up to 7 days; aliquot and store at -20°C for longer storage; avoid repeated freeze-thaw cycles 

• Powder Stability: Up to 3 years at -20°C 

Reconstitution Protocol:

1. Allow vial to reach room temperature

2. Add sterile bacteriostatic water, PBS (pH 7.2), or 0.9% sodium chloride solution 

3. Gently swirl (do not vortex) until fully dissolved

4. Dispense into individual aliquots to minimize freeze-thaw degradation

Note: Peptides are sensitive to formulation, process, and environmental conditions that may lead to aggregation and degradation.

Important Notice

⚠️ FOR RESEARCH USE ONLY

This product is not intended for human consumption, diagnostic use, therapeutic application, or clinical administration. Semax is a research chemical intended exclusively for in-vitro and laboratory research purposes.

• Not approved by the FDA for human use

• Not a dietary supplement, food additive, or pharmaceutical for over-the-counter purchase

• Not recommended for use during pregnancy or breastfeeding due to lack of safety research 

• Intended solely for qualified researchers and scientific institutions

By purchasing this product, you confirm that you are a licensed researcher or laboratory professional and agree to use this compound in compliance with all applicable local, national, and international regulations.

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Semax Peptide 5mg – >98% Purity
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