Sermorelin Peptide – Research Grade GHRH Analog

Product Overview

Sermorelin Peptide is a synthetic 29-amino acid peptide (GRF 1-29 NH₂) that corresponds to the amino-terminal segment of the naturally occurring human growth hormone-releasing hormone (GHRH), which consists of 44 amino acid residues . This N-terminal sequence is identical in several mammalian species, including human, pig, and cattle .

Sermorelin Peptide was originally FDA-approved in 1990 for diagnostic evaluation of pituitary function and for the treatment of growth hormone deficiency in children . The brand product was discontinued in 2008, but the compound remains a research-grade peptide for endocrine and metabolic studies .

⚠️ Research Context: This product is intended exclusively for in-vitro and laboratory research purposes. It is not approved by the FDA for over-the-counter human use.

Mechanism of Action

Sermorelin Peptide functions as a GHRH receptor agonist :

• GHRH Receptor Binding: Binds to the growth hormone-releasing hormone receptor on pituitary somatotroph cells, mimicking native GRF in its ability to stimulate growth hormone secretion 

• Pituitary Stimulation: Increases plasma growth hormone (GH) concentration by stimulating the pituitary gland to release GH 

• Physiological GH Release: Stimulates growth hormone secretion in a pulsatile pattern, preserving natural hormonal feedback mechanisms 

• IGF-1 Mediation: The released GH signals the liver to produce insulin-like growth factor 1 (IGF-1), the main mediator of GH’s positive effects 

Key Research Applications:

• Growth hormone axis and GHRH receptor signaling studies

• Pituitary function and endocrine regulation research

• Metabolic and body composition investigations

• Aging and age-related GH decline research

Product Specifications

Quality Assurance

Every batch of Sermorelin undergoes rigorous analytical testing to ensure maximum purity and research integrity: 

Certificate of Analysis (COA) available upon request.

Research Background

Pharmacodynamics & Mechanism

Sermorelin is similar to the full-length native hormone (44 residues) in its ability to stimulate GH secretion in humans . It binds to the GHRH receptor on the anterior pituitary to trigger GH release, functioning as a hormone stimulant that activates endogenous growth hormone production rather than delivering synthetic hormone directly . Sermorelin Peptide

Clinical & Regulatory Status

• FDA Status: Approved in 1990 for diagnostic evaluation of pituitary function and pediatric growth hormone deficiency 

• Market Status: Brand product discontinued in 2008 

• Primary Use (Historical): Treatment of children with growth hormone deficiency and growth failure 

• Off-Label Research Context: Investigated for acute or age-related growth hormone insufficiency 

Research Considerations

Sermorelin is one of the few authorized peptides in its class, but the original product was withdrawn from the market due to commercial reasons . It remains a compound of interest in endocrine research and aging studies. Sermorelin Peptide

Storage & Reconstitution Guidelines

Storage Conditions:

• Lyophilized (Long-term): -20°C, protected from light, dry, sealed

• Lyophilized (Short-term): 2°C – 8°C (refrigerated)

• Reconstituted: 4°C for up to 7 days; aliquot and store at -20°C for extended storage; avoid repeated freeze-thaw cycles

Reconstitution Protocol:

1. Allow vial to reach room temperature

2. Add sterile bacteriostatic water or 0.9% sodium chloride solution

3. Gently swirl (do not vortex) until fully dissolved

4. Dispense into individual aliquots to minimize freeze-thaw degradation

Note: Peptides are sensitive to formulation, process, and environmental conditions that may lead to aggregation and degradation. Sermorelin Peptide

Important Notice

⚠️ FOR RESEARCH USE ONLY

This product is not intended for human consumption, diagnostic use, therapeutic application, or clinical administration. Sermorelin Peptide is a research chemical intended exclusively for in-vitro and laboratory research purposes. 

• Not approved by the FDA for over-the-counter human use

• Not a dietary supplement, food additive, or pharmaceutical for over-the-counter purchase

• Intended solely for qualified researchers and scientific institutions

By purchasing this product, you confirm that you are a licensed researcher or laboratory professional and agree to use this compound in compliance with all applicable local, national, and international regulations. sermorelin peptide therapy

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Sermorelin Peptide 5mg – ≥99% Purity
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