DSIP Peptide (Delta Sleep-Inducing Peptide) – Research Grade
Product Overview
DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) first isolated in 1977 from the cerebral venous blood of rabbits during induced sleep . This neuropeptide is synthesized in the hypothalamus and is found in neurons, peripheral organs, and plasma . Its name originates from its first discovered physiological action: an EEG delta/spindles-inducing effect .
DSIP is unusual among peptides for its ability to freely cross the blood-brain barrier and its apparent absorption from the gastrointestinal tract without being fully denatured by enzymes . Research has since revealed a broader spectrum of activity beyond sleep regulation, including effects on stress response, neuroprotection, and endocrine modulation .
⚠️ Research Context: This product is intended exclusively for in-vitro and laboratory research purposes. It is not approved by the FDA for human use. The existence of a specific DSIP receptor and its definitive physiological role remain subjects of ongoing investigation .
Mechanism of Action
DSIP exerts its effects through multiple pathways, though a definitive high-affinity receptor has not yet been identified :
GABAergic System Modulation:
-
DSIP potentiates GABA-activated currents in hippocampal and cerebellar neurons, providing a plausible mechanism for its sedative and anticonvulsant effects
Glutamatergic System Modulation:
-
Blocks NMDA-activated potentiation in cortical and hippocampal neurons, potentially contributing to neuroprotective properties by mitigating excitotoxicity
Endocrine System Modulation:
-
Influences the hypothalamic-pituitary-adrenal (HPA) axis, decreasing basal corticotropin (ACTH) levels and reducing cortisol
-
May stimulate release of luteinizing hormone (LH) and growth hormone (GH)
Opioid System Interaction:
-
Has been found to act as an antagonist at opiate receptors, which may explain its observed effects in withdrawal management
Antioxidant Effects:
-
Demonstrates antioxidant properties, enhancing oxidative phosphorylation in mitochondria and reducing oxidative stress markers
Key Research Applications:
-
Sleep regulation and insomnia research
-
Stress response and HPA axis studies
-
Neuroprotection and excitotoxicity research
-
Withdrawal syndrome research (opioid/alcohol)
-
Circadian rhythm investigations
Product Specifications
| Parameter | Specification |
|---|---|
| Product Name | DSIP (Delta Sleep-Inducing Peptide) |
| Synonyms | Delta-Sleep Peptide, Emideltide, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu |
| CAS Number | 69431-45-4 |
| Molecular Formula | C₃₅H₄₈N₁₀O₁₅ |
| Molecular Weight | 848.8 g/mol |
| Sequence (One Letter) | WAGGDASGE |
| Sequence (Three Letter) | Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu |
| Purity | ≥98% (HPLC Verified) |
| Appearance | White lyophilized powder |
| Storage | -20°C (long-term); 2-8°C (short-term), protected from light, desiccated |
| Solubility | Soluble in sterile water (≥100 µg/mL); further dilution in aqueous solutions |
Quality Assurance
Every batch of DSIP undergoes rigorous analytical testing:
| Test | Method | Specification |
|---|---|---|
| Identity | ESI-MS / HPLC | Matches theoretical mass |
| Purity | RP-HPLC | ≥98% area |
| Sequence Confirmation | MS/MS | 100% sequence coverage |
| Endotoxin | LAL Test | <0.25 EU/mg |
| Sterility | USP <71> | No growth |
Certificate of Analysis (COA) available upon request.
Research Background
Discovery and Early Research
DSIP was first isolated in 1977 from the extracorporeal dialysate of venous blood from the sinus confluens of rabbits during electrical stimulation of the interlaminar thalamus . Its sleep-promoting effects were demonstrated in rabbits, mice, rats, cats, and human beings . DSIP promotes a particular type of sleep characterized by an increase in the delta rhythm of the EEG .
Pharmacokinetic Properties
-
Plasma half-life: 7-8 minutes
-
Blood-brain barrier: Freely crosses the BBB
-
Bioavailability (SC): ~80%
-
Protein binding: ~99%
-
In vitro half-life: ~15 minutes
Transport and Metabolism Research
DSIP is rapidly metabolized in intestinal epithelial cell models. Research using Caco-2 cell monolayers identified that the peptide is rapidly metabolized when applied to the apical side (8.2% remaining after 2 hours), with Trp as the major metabolite. Aminopeptidase inhibitors increased stability substantially (95.1% remaining after 2 hours with combined inhibitors), though no intact DSIP was detected on the basolateral side .
Sleep Research Findings
Studies on DSIP’s sleep-promoting effects have produced mixed results:
-
Original rabbit studies demonstrated increased delta wave sleep
-
Some preclinical studies reproduced these effects, but not all
-
Studies on efficiency of DSIP in insomnia treatment have produced conflicting results
-
DSIP has been described as a “sleep-promoting substance” rather than a sedative, with greater activity when sleep is disturbed and minimal effects in healthy subjects
-
Dosing timing is critical: a dose given during the day may promote improved sleep on the following night and for several nights thereafter
Non-Sleep Research
Neuroprotection:
-
Anticonvulsant action in rats (increases threshold to NMDA- and picrotoxin-induced convulsions)
-
Reduced mortality and post-ischemia dysfunction in bilateral carotid ligation models
-
Reduced brain swelling in toxic cerebral edema models
Stress and Endocrine:
-
Attenuates emotional and psychological responses to stress in rats
-
Reduces central amine responses to stress
-
May decrease ACTH secretion and modulate the HPA axis
-
Paradoxically, plasma DSIP concentrations exhibit diurnal variation, with low concentrations in the morning and higher in the afternoon
Withdrawal Research:
-
Has been studied for treatment of alcohol and opioid withdrawal with some reported success
Clinical Study Challenges
The existence of a specific DSIP receptor has not been definitively confirmed . Some research suggests DSIP may be of bacterial origin . A BLAST search of the peptide sequence showed alignment with hypothetical proteins in Amycolatopsis coloradensis and other bacterial species, raising this possibility . Administration of synthetic DSIP does not appear to induce tolerance .
Storage & Reconstitution Guidelines
Storage Conditions:
-
Lyophilized (Long-term): -20°C, protected from light, dry, sealed
-
Lyophilized (Short-term): 2°C – 8°C (refrigerated)
-
Reconstituted: 4°C for up to 7 days; aliquot and store at -20°C for longer storage; avoid repeated freeze-thaw cycles
-
Long-term storage: Add a carrier protein (0.1% HSA or BSA)
Reconstitution Protocol:
-
Allow vial to reach room temperature
-
Add sterile 18 MΩ-cm H₂O or bacteriostatic water (minimum 100 µg/mL)
-
Gently swirl (do not vortex) until fully dissolved
-
Dispense into individual aliquots to minimize freeze-thaw degradation
Important Notice
⚠️ FOR RESEARCH USE ONLY
This product is not intended for human consumption, diagnostic use, therapeutic application, or clinical administration. DSIP is a research chemical intended exclusively for in-vitro and laboratory research purposes.
-
Not approved by the FDA for human use
-
Not a dietary supplement, food additive, or pharmaceutical for over-the-counter purchase
-
No definitive receptor identified and mechanism of action remains incompletely characterized
-
Clinical evidence is mixed, particularly for sleep applications
-
Intended solely for qualified researchers and scientific institutions
By purchasing this product, you confirm that you are a licensed researcher or laboratory professional and agree to use this compound in compliance with all applicable local, national, and international regulations.
Why Choose PeptidesUnit.com?
| Feature | Benefit |
|---|---|
| ✅ Premium Purity | ≥98% HPLC-verified purity guaranteed |
| ✅ Research-Grade Quality | Manufactured under controlled laboratory conditions |
| ✅ Third-Party Tested | Independent COA for every batch |
| ✅ Secure Packaging | Lyophilized in amber glass vials with tamper-evident seals |
| ✅ Fast Global Shipping | Discreet packaging with real-time tracking |
| ✅ Competitive Pricing | Direct-from-manufacturer pricing |
Order Now
DSIP Peptide 5mg – ≥98% Purity
Available for immediate shipment
🛒 BUY NOW at PeptidesUnit.com
For bulk orders (10+ vials), custom peptide synthesis, or wholesale inquiries, please contact our sales team at sales@peptidesunit.com. peptide dsip
| Dosage | 5mg, 10mg |
|---|
39 reviews for DSIP
Add a review
Related products
Dr. Mark Sullivan –
I’ve been ordering research peptides from PeptidesUnit for over a year now and their consistency is unmatched. The purity and quality are always top-notch
Sarah Mitchell –
Absolutely thrilled with my order from PeptidesUnit. The peptides arrived quickly
James Rodriguez –
Really satisfied with PeptidesUnit’s products. The shipping was prompt and the peptides were exactly as described. Giving 4 stars only because I wish they offered more payment options
Emily Chen –
PeptidesUnit is my go-to source for research materials. Their prices are competitive
David Wilson –
I was a bit skeptical ordering online at first
Laura Martinez –
Good experience overall with PeptidesUnit. The product quality is great and shipping was fast. Giving 4 stars because I had a minor issue with the vial packaging
Robert Taylor –
I’ve tried several peptide suppliers and PeptidesUnit is by far the best. Their quality control is evident in every product. The peptides are pure
Amanda White –
PeptidesUnit made my first research purchase so easy. Their website is user-friendly
Kevin Brown –
I’ve been a loyal customer for several months now and PeptidesUnit has never disappointed. The quality is consistently excellent and their shipping is lightning fast. They are a trustworthy and reliable supplier. Highly recommend!
Jessica Lee –
Very happy with my purchase from PeptidesUnit. The product quality is excellent and the price is reasonable. Giving 4 stars because the tracking information could be more detailed
Daniel Miller –
PeptidesUnit is a game-changer for researchers. Their peptides are of the highest purity and their customer service is second to none. I’ve recommended them to all my colleagues. Excellent company!
Michelle Garcia –
I’m so glad I found PeptidesUnit. Their products are fantastic and their shipping is always on time. They make ordering research materials so simple and stress-free. Highly recommended for anyone in the field!
Brian Martinez –
Really solid experience with PeptidesUnit. The product quality is top-tier and the order arrived promptly. Giving 4 stars because the website could be a bit more modern
Nicole Anderson –
PeptidesUnit exceeded all my expectations. The quality of their peptides is amazing and their customer service team is incredibly helpful and friendly. I will never use another supplier. Five stars all the way!
Jason Thomas –
I’ve ordered multiple times from PeptidesUnit and every single order has been perfect. Their peptides are high-quality
Rachel Kim –
Great products and fast shipping from PeptidesUnit. I’m very satisfied with my order. Giving 4 stars because the packaging could be a bit more discreet
Steven Park –
PeptidesUnit is simply the best. Their commitment to quality and customer satisfaction is unmatched. Every order I’ve placed has arrived quickly and in perfect condition. I couldn’t be happier with their service!
Jennifer Davis –
I recently started using PeptidesUnit for my research and I’m thoroughly impressed. The peptides are pure and effective
Christopher Wilson –
This was my first time ordering from PeptidesUnit and I was blown away by the quality and service. The products arrived very quickly and the customer support was outstanding. I will definitely be a returning customer!
Ashley Moore –
Very good experience with PeptidesUnit. The product quality is excellent and the shipping was fast. Giving 4 stars because I wish they offered a loyalty program for repeat customers
Matthew Taylor –
PeptidesUnit is my absolute favorite supplier. Their peptides are always high-quality
Stephanie White –
I’ve been using PeptidesUnit for my research needs for a while now and they never disappoint. The quality is consistently excellent and their customer service is top-notch. Highly recommend them to anyone looking for quality peptides!
Andrew Harris –
Really pleased with my order from PeptidesUnit. The product arrived quickly and the quality was great. Giving 4 stars because the communication about the order status could be improved
Laura Martin –
PeptidesUnit is fantastic! Their products are of the highest quality and their shipping is super fast. I’ve never had any issues with them and they always deliver on their promises. Highly recommended!
Gregory Nelson –
I’ve used many peptide suppliers
Megan O’Brien –
Great experience with PeptidesUnit. The product quality is excellent and the shipping was fast and secure. Giving 4 stars because I wish they had a wider selection of peptides
Ryan Murphy –
PeptidesUnit is hands down the best peptide supplier out there. Their quality is unmatched
Olivia Carter –
I’m very impressed with PeptidesUnit. Their products are amazing and they always arrive on time. The ordering process is simple and their team is very professional. Highly recommended for all your research needs!
Tyler Adams –
Very satisfied with my purchase from PeptidesUnit. The product quality is excellent and the price is reasonable. Giving 4 stars because the packaging could be more secure
Brittany Foster –
PeptidesUnit is my trusted source for research peptides. Their quality is consistently outstanding and their shipping is always reliable. I’ve never been disappointed with them. Highly recommend!
Nathan Reed –
I recently discovered PeptidesUnit and I’m so glad I did. Their products are top-quality and their customer service is excellent. They answered all my questions promptly and my order arrived very quickly. Five stars!
Chelsea Cox –
Really good experience with PeptidesUnit. The product quality is great and the shipping was fast. Giving 4 stars because the website could be more intuitive
Derek Powell –
PeptidesUnit is the only supplier I trust for my research. Their quality is superb
Hannah Ward –
I can’t say enough good things about PeptidesUnit. Their products are amazing and they always deliver on time. Their customer service team is also very helpful and responsive. Truly a top-tier supplier!
Eric Simmons –
Very happy with my order from PeptidesUnit. The product quality is excellent and the shipping was prompt. Giving 4 stars because I think they could improve their packaging for better protection
Vanessa Ross –
PeptidesUnit is my favorite peptide supplier. Their products are always high-quality and their shipping is lightning fast. They are incredibly reliable and I trust them completely with my research needs. Highly recommend!
Keith Flores –
I’ve ordered from PeptidesUnit several times and they have never let me down. Their quality is consistently outstanding and their customer service is excellent. They are definitely the best in the business. Five stars!
Kimberly Coleman –
Great experience with PeptidesUnit overall. The product quality is fantastic and the shipping was fast. Giving 4 stars because I wish they offered overnight shipping options
Jonathan Hayes –
PeptidesUnit is absolutely fantastic! Their products are of the highest quality and their service is impeccable. I’ve recommended them to all my friends and colleagues. If you’re looking for quality peptides