HGH Fragment 176-191 Peptide (AOD 9604) – Research Grade

Product Overview

HGH frag 176 191 (also known as AOD 9604) is a synthetic 16-amino acid peptide fragment derived from the C-terminal region of human growth hormone (hGH), corresponding to amino acid residues 176–191 . This peptide was developed by Metabolic Pharmaceuticals in the late 1990s as a research tool to isolate and study the lipolytic (fat breakdown) properties of growth hormone while minimizing effects on insulin sensitivity and IGF-1 levels.

The peptide’s structure incorporates an additional tyrosine residue at the N-terminus, a modification theorized to support stability and activity . Unlike full-length growth hormone, HGH frag 176 191 is hypothesized to selectively target pathways involved in lipid metabolism without significantly impacting insulin or IGF-1 levels .

⚠️ Research Context: This peptide is listed on the World Anti-Doping Agency (WADA) Prohibited List (Section S2.2) and is not FDA-approved for human use . It is intended exclusively for laboratory research purposes.

Mechanism of Action

HGH frag 176 191 functions through pathways distinct from full-length growth hormone :

• Lipolysis Stimulation: Promotes the breakdown of stored fat (triglycerides) into free fatty acids 

• Lipogenesis Inhibition: Reduces the formation of new fat deposits 

• Receptor Independence: Does not activate GH receptors, minimizing endocrine effects 

• Fat Oxidation Enhancement: Increases lipid oxidation without stimulating IGF-1 or GH signaling 

Key Research Applications:

• Adipose tissue metabolism and fat oxidation studies 

• Lipid profile and metabolic regulation research 

• Cartilage regeneration and tissue repair studies 

• Obesity and metabolic syndrome pathway investigations 

Product Specifications

Quality Assurance

Every batch of HGH frag 176 191 undergoes rigorous analytical testing to ensure maximum purity and research integrity:

Certificate of Analysis (COA) available upon request.

Research Background

Development History

HGH frag 176 191 was originally developed by Metabolic Pharmaceuticals in the late 1990s for obesity research . However, it “did not show a clinically meaningful weight loss outcome across the trial population” . The peptide has since been studied in various research contexts including lipid metabolism, cartilage repair, and tissue regeneration .

Preclinical Research

Clinical & Regulatory Status

• FDA Status: Not approved for human use; Category 2 bulk drug substance 

• WADA Status: Prohibited (Section S2.2) 

• Research Use: Sold online only as a research chemical; not authorized for clinical treatment 

• Clinical Trials: Limited data; no clinically meaningful weight loss outcome demonstrated in trial populations 

Storage & Reconstitution Guidelines

Storage Conditions:

• Lyophilized (Long-term): -20°C, protected from light and moisture 

• Lyophilized (Short-term): 2°C – 8°C (refrigerated) 

• Reconstituted: 4°C for up to 7 days; aliquot and store at -20°C for longer storage; avoid repeated freeze-thaw cycles

Reconstitution Protocol:

1. Allow vial to reach room temperature

2. Add sterile bacteriostatic water or 0.9% sodium chloride solution

3. Gently swirl (do not vortex) until fully dissolved

4. For long-term storage, aliquot to minimize freeze-thaw degradation

Note: Peptides are sensitive to formulation, process, and environmental conditions that may lead to aggregation and degradation.

Important Notice

⚠️ FOR RESEARCH USE ONLY

This product is not intended for human consumption, diagnostic use, therapeutic application, or clinical administration. HGH Fragment 176-191 is a research chemical intended exclusively for in-vitro and laboratory research purposes.

• Not approved by the FDA for human use 

• Not a dietary supplement, food additive, or pharmaceutical

• Listed on the WADA Prohibited List (Section S2.2) 

• Intended solely for qualified researchers and scientific institutions 

By purchasing this product, you confirm that you are a licensed researcher or laboratory professional and agree to use this compound in compliance with all applicable local, national, and international regulations.

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HGH frag 176 191 (AOD 9604) Peptide 5mg – ≥99% Purity
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