Hexarelin Acetate

Hexarelin Acetate Peptide – Research Grade GHS

Hexarelin Acetate (Examorelin) is a potent, synthetic hexapeptide analog of Growth Hormone-Releasing Peptide-6 (GHRP-6) . Its structure, His-D-2-Me-Trp-Ala-Trp-D-Phe-Lys-NH₂, incorporates a D-2-methyl-tryptophan substitution that confers enhanced enzymatic stability and a longer plasma half-life (55–70 minutes) compared to earlier GHRPs . It functions as a powerful growth hormone secretagogue (GHS) and a dual agonist for the ghrelin receptor (GHSR-1a) and CD36 receptor .

⚠️ Research Context: This product is intended exclusively for in-vitro and laboratory research purposes. It is not approved by the FDA for human use.

Mechanism of Action

Hexarelin exerts its effects primarily through the activation of multiple signaling pathways:

Primary GH Secretagogue Action (GHSR-1a):

• Binds to the ghrelin/growth hormone secretagogue receptor (GHSR-1a) predominantly expressed in the hypothalamus and pituitary .

• Activates the Gq/11 protein and downstream Phospholipase C (PLC) pathway, leading to IP₃ and DAG production, which triggers intracellular calcium release and GH exocytosis .

Cardioprotective Receptor (CD36):

• Unlike other GHRPs, Hexarelin also binds with high affinity to the non-GHSR receptor CD36, which mediates GH-independent cardioprotective effects .

ACTH and Cortisol Release:

• Clinical research demonstrates Hexarelin possesses a notable ACTH- and cortisol-releasing activity, overlapping with that of AVP and similar to hCRH .

• This effect appears to be independent of CRH-mediated mechanisms and is dramatically enhanced in patients with Cushing’s disease .

Key Research Applications:

• Growth hormone axis and receptor signaling studies

• Cardioprotection and ischemia/reperfusion research

• Hypothalamic-pituitary-adrenal (HPA) axis investigations

• Comparison studies with other GHS (e.g., Ipamorelin, GHRP-6)

Product Specifications

Certificate of Analysis (COA) available upon request.

Research Background

Key Research Findings

Research Considerations

• Hexarelin is structurally similar to GHRP-6 but does not significantly increase ghrelin levels, meaning it may have less effect on appetite stimulation compared to some other GHRPs .

• Studies indicate Hexarelin shows no synergistic interaction with CRH or AVP on ACTH/cortisol secretion, suggesting its effect on the HPA axis is at least partially independent of these pathways .

• In rat models, Hexarelin’s GH-releasing activity requires functional GHRH pathways . hexarelin acetate

Storage & Reconstitution Guidelines

Storage Conditions:

• Lyophilized (Long-term): -20°C, protected from light, dry, sealed 

• Lyophilized (Short-term): 2°C – 8°C (refrigerated)

• Reconstituted: 4°C for up to 7 days; aliquot and store at -20°C for extended storage; avoid repeated freeze-thaw cycles

Reconstitution Protocol:

1. Allow vial to reach room temperature

2. Add sterile bacteriostatic water or 0.9% sodium chloride solution

3. Gently swirl (do not vortex) until fully dissolved

4. Dispense into individual aliquots to minimize freeze-thaw degradation

Important Notice

⚠️ FOR RESEARCH USE ONLY

This product is not intended for human consumption, diagnostic use, therapeutic application, or clinical administration. Hexarelin Acetate is a research chemical intended exclusively for in-vitro and laboratory research purposes.

• Not approved by the FDA for human use

• Not a dietary supplement, food additive, or pharmaceutical for over-the-counter purchase

• Research-grade product — not a medicinal product 

• Intended solely for qualified researchers and scientific institutions

By purchasing this product, you confirm that you are a licensed researcher or laboratory professional and agree to use this compound in compliance with all applicable local, national, and international regulations.

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Hexarelin Acetate Peptide 5mg – ≥98% Purity
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