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survodutide peptide

Survodutide

$326.00

Survodutide (BI 456906) — Research Grade Peptide

  • Dual GCGR/GLP-1R agonist (oxyntomodulin analog)

  • ≥98% purity (HPLC), MS-confirmed identity

  • Lyophilized powder · CAS 2805997-46-8 · C₁₉₂H₂₈₉N₄₇O₆₁

  • Lot-specific COA included

  • For research use only

99%+
Purity grade
24h
Dispatch
3rd
Party tested
Certificate of Analysis
Included with every batch
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Product Details

Survodutide Peptide (BI 456906) — Research Grade Peptide, ≥98% Purity (HPLC)

Dual GCGR/GLP-1R agonist. Oxyntomodulin analog. Lyophilized powder. Lot-specific COA included.

Survodutide, also known as BI 456906, is an investigational once-weekly dual agonist at the glucagon receptor (GCGR) and the glucagon-like peptide-1 receptor (GLP-1R). The compound is designed to replicate the actions of oxyntomodulin, an endogenous GCGR/GLP-1R dual agonist that influences body weight and liver health. Its proposed mechanism combines reduced food intake through GLP-1 receptor agonism with glucagon receptor-mediated effects on energy expenditure and hepatic metabolism. Preclinical studies indicate that Survodutide peptide acts through circumventricular organs in the brain and activates neuronal regions associated with appetite regulation, including GLP-1R–expressing satiety nuclei.

The dual mechanism distinguishes Survodutide peptide from selective GLP-1 receptor agonists. GLP-1R activation mediates insulin secretion, appetite suppression, and gastric emptying, while GCGR activation increases energy expenditure and hepatic fatty acid oxidation. In Phase 2 trials, participants assigned to the 4.8-mg dose achieved a mean body-weight reduction of up to 18.7% at 46 weeks, compared with 2.3% with placebo.

Supplied as a sterile-filtered, lyophilized powder for in vitro and preclinical research applications. Each lot is independently verified for purity and identity and ships with a Certificate of Analysis. Survodutide peptide

Specifications

Parameter Detail
CAS Number 2805997-46-8
Molecular Formula C₁₉₂H₂₈₉N₄₇O₆₁
Molecular Weight 4231.63 g/mol
Sequence H-His-{1-Aminocyclobutanecarboxylic acid}-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Glu-Arg-Ala-Ala-Lys-Asp-Phe-Ile-{Lys(Gly-Ser-Gly-Ser-Gly-Gly-γGlu-C18 diacid)}-Trp-Leu-Glu-Ser-Ala-NH₂
Purity ≥98% (HPLC)
Identity Confirmed by mass spectrometry
Appearance White to off-white lyophilized powder
Solubility Soluble in water and aqueous buffers
Storage −20 °C, desiccated, protected from light
Format Lyophilized powder, sterile-filtered
Documentation Lot-specific COA (HPLC + MS)

Note: Survodutide peptide is supplied in both free base and salt forms. Verify the exact form, molecular weight, and purity against the Certificate of Analysis supplied with your lot. Independent testing of commercial Survodutide products has reported purity ranging from 99.87% to 99.95% in some samples, with fill deviations up to +7% relative to stated amounts.

Research applications

Survodutide is used in laboratory settings to investigate:

  • Dual incretin receptor signaling — simultaneous activation of GCGR and GLP-1R, and downstream cAMP accumulation via adenylyl cyclase in transfected cell lines

  • Hepatic lipid metabolism and MASH/MASLD research — suppression of lipid uptake, de novo lipogenesis, and lipid droplet formation, with most adults with obesity and serious fatty liver disease reaching at least a 30% reduction in liver fat over 48 weeks in Phase 3 trials

  • Energy expenditure and adipose tissue research — GCGR-mediated lipolysis and thermogenesis in diet-induced obese (DIO) mouse models

  • Circumventricular organ signaling — activation of neuronal regions associated with appetite regulation and satiety nuclei

  • Glycemic control research — HbA1c reductions up to 1.21% from baseline in adults with obesity and type 2 diabetes in Phase 3 trials

  • Analytical method development — LC-MS/MS quantification and reference standard preparation for dual agonist peptide analysis

Handling and storage

Reconstitute under aseptic conditions using sterile water or an appropriate aqueous buffer. Survodutide peptide is soluble in water. Aliquot immediately after reconstitution to avoid repeated freeze-thaw cycles. Lyophilized powder is stable for up to 2 years at −20 °C under sealed, desiccated, light-protected conditions. Reconstituted solutions should be stored at 2–8 °C and used within 14–21 days. Do not freeze reconstituted solution.

Survodutide peptide For laboratory use by qualified personnel only. Survodutide research grade

23 reviews for Survodutide

  1. Ava Thompson –

    Fast shipping and excellent peptide quality. Packaging was discreet and professional.

  2. Liam Carter –

    Product arrived quickly and purity matched the COA. Very reliable vendor.

  3. Sophia Nguyen –

    Good quality peptides and easy ordering process. Shipping was prompt.

  4. Noah Bennett –

    Great customer service and fast delivery. Product worked exactly as expected.

  5. Mia Rodriguez –

    Secure checkout and sterile packaging. I was impressed with the quality.

  6. Ethan Walker –

    Competitive pricing and reliable products. Delivery took a few days but was smooth.

  7. Isabella Kim –

    Excellent purity and professional service. Will definitely order again.

  8. Mason Clark –

    Batch-specific COA included and product quality was top-notch. Highly recommend.

  9. Amelia Davis –

    Good experience overall. Peptides were as described and shipping was quick.

  10. Lucas Martinez –

    Fast and discreet shipping. Product integrity was perfect and support was helpful.

  11. Harper Lewis –

    Very satisfied with the quality and speed of delivery. Trustworthy supplier.

  12. Oliver Young –

    Solid vendor with fair prices. Products arrived well packaged and on time.

  13. Evelyn Hall –

    Excellent customer support and high-quality peptides. Five stars.

  14. Elijah Allen –

    Smooth ordering and quick delivery. Purity was exactly as stated.

  15. Chloe Wright –

    Good quality and responsive support. Shipping was slightly delayed but resolved.

  16. James Scott –

    Reliable source with great COAs. Product worked perfectly in my research.

  17. Grace Baker –

    Discreet packaging and fast arrival. Very happy with the product quality.

  18. Benjamin Reed –

    Easy website and secure checkout. Peptides were high quality and well packed.

  19. Lily Morgan –

    Impressive purity and professional packaging. Highly recommend Peptides Unit.

  20. Henry Foster –

    Fast shipping and excellent customer service. Will definitely reorder.

  21. Zoe Mitchell –

    Reliable vendor with good pricing. Product arrived quickly and as described.

  22. Samuel Turner –

    Great communication and top-notch peptides. Very satisfied with my order.

  23. Nora Phillips –

    Secure packaging and fast delivery. Product quality exceeded expectations.

Add a review

23 reviews for Survodutide

  1. Ava Thompson –

    Fast shipping and excellent peptide quality. Packaging was discreet and professional.

  2. Liam Carter –

    Product arrived quickly and purity matched the COA. Very reliable vendor.

  3. Sophia Nguyen –

    Good quality peptides and easy ordering process. Shipping was prompt.

  4. Noah Bennett –

    Great customer service and fast delivery. Product worked exactly as expected.

  5. Mia Rodriguez –

    Secure checkout and sterile packaging. I was impressed with the quality.

  6. Ethan Walker –

    Competitive pricing and reliable products. Delivery took a few days but was smooth.

  7. Isabella Kim –

    Excellent purity and professional service. Will definitely order again.

  8. Mason Clark –

    Batch-specific COA included and product quality was top-notch. Highly recommend.

  9. Amelia Davis –

    Good experience overall. Peptides were as described and shipping was quick.

  10. Lucas Martinez –

    Fast and discreet shipping. Product integrity was perfect and support was helpful.

  11. Harper Lewis –

    Very satisfied with the quality and speed of delivery. Trustworthy supplier.

  12. Oliver Young –

    Solid vendor with fair prices. Products arrived well packaged and on time.

  13. Evelyn Hall –

    Excellent customer support and high-quality peptides. Five stars.

  14. Elijah Allen –

    Smooth ordering and quick delivery. Purity was exactly as stated.

  15. Chloe Wright –

    Good quality and responsive support. Shipping was slightly delayed but resolved.

  16. James Scott –

    Reliable source with great COAs. Product worked perfectly in my research.

  17. Grace Baker –

    Discreet packaging and fast arrival. Very happy with the product quality.

  18. Benjamin Reed –

    Easy website and secure checkout. Peptides were high quality and well packed.

  19. Lily Morgan –

    Impressive purity and professional packaging. Highly recommend Peptides Unit.

  20. Henry Foster –

    Fast shipping and excellent customer service. Will definitely reorder.

  21. Zoe Mitchell –

    Reliable vendor with good pricing. Product arrived quickly and as described.

  22. Samuel Turner –

    Great communication and top-notch peptides. Very satisfied with my order.

  23. Nora Phillips –

    Secure packaging and fast delivery. Product quality exceeded expectations.

Add a review

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