TB-500
Price range: $49.00 through $176.00
TB-500 (Thymosin β4 Fragment 17–23) — Research Grade Peptide
-
Synthetic thymosin β4 fragment (17LKKTETQ23, N-acetylated)
-
G-actin binding — regulates actin polymerization and cytoskeleton dynamics
-
≥98% purity (HPLC), MS-confirmed identity
-
Lyophilized powder · CAS 885340-08-9 · C₃₈H₆₈N₁₀O₁₄
-
Lot-specific COA included
-
For research use only
Product Details
TB500 Peptide (Thymosin β4 Fragment 17–23) — Research Grade Peptide, ≥98% Purity (HPLC)
Synthetic actin-binding peptide. Lyophilized powder. Lot-specific COA included.
TB500 Peptide is a synthetic heptapeptide corresponding to the active region (17LKKTETQ23) of the naturally occurring protein thymosin β4. The sequence is N-terminally acetylated (Ac-LKKTETQ), a modification that distinguishes the synthetic research peptide from the unacetylated fragment found in vivo. The 17LKKTETQ23 segment is the region within thymosin β4 responsible for actin binding, cell migration, and wound healing activity.
The peptide’s primary mechanism involves binding to G-actin, the monomeric building block of actin filaments, thereby preventing its polymerization into F-actin and maintaining the stability of the intracellular G-actin pool. This regulation of actin dynamics is critical for cytoskeleton remodeling, cell migration, and cell differentiation. TB500 Peptide
Supplied as a sterile-filtered, lyophilized powder for in vitro and preclinical research applications. Each lot is independently verified for purity and identity and ships with a Certificate of Analysis.
Specifications
| Parameter | Detail |
|---|---|
| CAS Number | 77591-33-4 (full-length Tβ4); 885340-08-9 (TB-500 acetate) |
| Molecular Formula | C₂₁₂H₃₅₀N₅₆O₇₈S (full-length); C₃₈H₆₈N₁₀O₁₄ (acetate) |
| Molecular Weight | 4963.44 g/mol (full-length); 889.01 g/mol (acetate) |
| Purity | ≥98% (HPLC) |
| Identity | Confirmed by mass spectrometry |
| Appearance | White to off-white lyophilized powder |
| Solubility | ≥2 mg/mL in H₂O |
| Storage | −20 °C, desiccated, protected from light, under nitrogen |
| Format | Lyophilized powder, sterile-filtered |
| Documentation | Lot-specific COA (HPLC + MS) |
Note: Suppliers list TB-500 with two distinct CAS numbers and molecular weights because the product is offered both as the full-length thymosin β4 protein and as the 17–23 acetate fragment. Verify the exact form and molecular weight against the Certificate of Analysis supplied with your lot. TB500 Peptide
Research applications
TB-500 is used in laboratory settings to investigate:
-
Actin cytoskeleton dynamics — G-actin binding and its effects on actin polymerization, cell migration, and cytoskeletal remodeling in cell culture models
-
Wound healing and tissue repair — keratinocyte migration, collagen deposition, and endothelial cell differentiation in dermal tissue models
-
Anti-fibrotic signaling — inhibition of the Akt signaling pathway and its downstream effects on fibrotic markers in vitro
-
Cell migration assays — promotion of cell migration at 15–25 μg/mL over 48 hours in PAM212 cell lines
-
Corneal repair research — enzyme-responsive peptide hydrogels incorporating TB500 for spatiotemporal repair of corneal injury
-
Cardiovascular biomarker studies — Phase 1/2 evaluation of TB-500 (thymosin β4 17–23 fragment) in adults with stable atherosclerotic cardiovascular disease (ASCVD)
Handling and storage
Reconstitute under aseptic conditions using sterile water. TB-500 is soluble in water at ≥2 mg/mL. Aliquot immediately after reconstitution to avoid repeated freeze-thaw cycles. Lyophilized powder is stable for up to 2 years at −80 °C or 1 year at −20 °C under sealed, desiccated, nitrogen-atmosphere conditions. Reconstituted solutions should be stored at −80 °C for longer-term use or −20 °C for short-term use. TB500 Peptide
For laboratory use by qualified personnel only.
23 reviews for TB-500
Add a review
23 reviews for TB-500
-
Fast shipping and excellent peptide quality. Packaging was discreet and professional.
-
Product arrived quickly and purity matched the COA. Very reliable vendor.
-
Good quality peptides and easy ordering process. Shipping was prompt.
-
Great customer service and fast delivery. Product worked exactly as expected.
-
Secure checkout and sterile packaging. I was impressed with the quality.
-
Competitive pricing and reliable products. Delivery took a few days but was smooth.
-
Excellent purity and professional service. Will definitely order again.
-
Batch-specific COA included and product quality was top-notch. Highly recommend.
-
Good experience overall. Peptides were as described and shipping was quick.
-
Fast and discreet shipping. Product integrity was perfect and support was helpful.
-
Very satisfied with the quality and speed of delivery. Trustworthy supplier.
-
Solid vendor with fair prices. Products arrived well packaged and on time.
-
Excellent customer support and high-quality peptides. Five stars.
-
Smooth ordering and quick delivery. Purity was exactly as stated.
-
Good quality and responsive support. Shipping was slightly delayed but resolved.
-
Reliable source with great COAs. Product worked perfectly in my research.
-
Discreet packaging and fast arrival. Very happy with the product quality.
-
Easy website and secure checkout. Peptides were high quality and well packed.
-
Impressive purity and professional packaging. Highly recommend Peptides Unit.
-
Fast shipping and excellent customer service. Will definitely reorder.
-
Reliable vendor with good pricing. Product arrived quickly and as described.
-
Great communication and top-notch peptides. Very satisfied with my order.
-
Secure packaging and fast delivery. Product quality exceeded expectations.
Add a review
Related products
Ava Thompson –
Fast shipping and excellent peptide quality. Packaging was discreet and professional.
Liam Carter –
Product arrived quickly and purity matched the COA. Very reliable vendor.
Sophia Nguyen –
Good quality peptides and easy ordering process. Shipping was prompt.
Noah Bennett –
Great customer service and fast delivery. Product worked exactly as expected.
Mia Rodriguez –
Secure checkout and sterile packaging. I was impressed with the quality.
Ethan Walker –
Competitive pricing and reliable products. Delivery took a few days but was smooth.
Isabella Kim –
Excellent purity and professional service. Will definitely order again.
Mason Clark –
Batch-specific COA included and product quality was top-notch. Highly recommend.
Amelia Davis –
Good experience overall. Peptides were as described and shipping was quick.
Lucas Martinez –
Fast and discreet shipping. Product integrity was perfect and support was helpful.
Harper Lewis –
Very satisfied with the quality and speed of delivery. Trustworthy supplier.
Oliver Young –
Solid vendor with fair prices. Products arrived well packaged and on time.
Evelyn Hall –
Excellent customer support and high-quality peptides. Five stars.
Elijah Allen –
Smooth ordering and quick delivery. Purity was exactly as stated.
Chloe Wright –
Good quality and responsive support. Shipping was slightly delayed but resolved.
James Scott –
Reliable source with great COAs. Product worked perfectly in my research.
Grace Baker –
Discreet packaging and fast arrival. Very happy with the product quality.
Benjamin Reed –
Easy website and secure checkout. Peptides were high quality and well packed.
Lily Morgan –
Impressive purity and professional packaging. Highly recommend Peptides Unit.
Henry Foster –
Fast shipping and excellent customer service. Will definitely reorder.
Zoe Mitchell –
Reliable vendor with good pricing. Product arrived quickly and as described.
Samuel Turner –
Great communication and top-notch peptides. Very satisfied with my order.
Nora Phillips –
Secure packaging and fast delivery. Product quality exceeded expectations.