Survodutide Peptide (BI 456906) – Research Grade Dual GLP-1/Glucagon Receptor Agonist

Product Overview

Survodutide (also known as BI 456906) is a synthetic 29-amino-acid peptide and balanced dual agonist of the glucagon receptor (GCGR) and the glucagon-like peptide-1 receptor (GLP-1R) . It is based on the hormone oxyntomodulin and incorporates structural modifications designed to enhance stability and enable once-weekly administration in research models .

Survodutide is currently in Phase 3 clinical trials for obesity and Phase 2 for metabolic dysfunction-associated steatohepatitis (MASH). Early trial results show it outperformed semaglutide for weight outcomes while maintaining comparable glycemic efficacy . It was designed with an 8:1 receptor bias favoring GLP-1R over GCGR to balance metabolic benefits and tolerability .

⚠️ Research Context: This product is intended exclusively for in-vitro and laboratory research purposes.

Mechanism of Action

Survodutide functions through balanced activation of both GLP-1 and glucagon receptors :

GLP-1 Receptor Activation:

• Suppresses appetite and slows gastric emptying

• Enhances insulin secretion and glycemic control

Glucagon Receptor Activation:

• Increases energy expenditure and basal metabolic rate 

• Promotes fatty acid oxidation and hepatic fat breakdown

• Directly reduces liver fat accumulation 

Dual Synergy:

• Greater weight loss than GLP-1 monotherapy via increased energy expenditure and reduced food intake

• Activates cAMP signaling, insulin secretion, and glucagon signaling pathways 

Key Research Applications:

• Metabolic regulation and energy homeostasis

• Hepatic steatosis and MASH research

• GLP-1/glucagon receptor co-agonism pharmacology

• Adipose tissue metabolism and thermogenesis

Product Specifications

Quality Assurance

Every batch undergoes rigorous analytical testing to ensure maximum purity and research integrity:

Certificate of Analysis (COA) available upon request.

Research Background

Key Preclinical Data 

Phase 2 Clinical Trial Data

Obesity (46 weeks) :

• Up to 18.7% body weight reduction

• Superior to semaglutide for weight outcomes 

• HbA1c reduction up to −1.71% 

MASH (48 weeks) :

• 83% of participants showed MASH improvement without worsening of fibrosis (vs. 18.2% placebo)

• Statistically significant liver fibrosis improvement in secondary endpoint

Safety & Tolerability 

• Most common adverse events: gastrointestinal (nausea, vomiting, diarrhea)

• Modest heart rate increases noted

• Higher discontinuation rates than placebo, primarily during dose escalation 

• Meta-analysis confirmed higher risk of diarrhea 

• Survival ongoing in SYNCHRONIZE-CVOT outcomes trial 

Storage & Reconstitution Guidelines

Storage Conditions:

• Lyophilized (Long-term): -20°C, protected from light, dry, sealed 

• Lyophilized (Short-term): 2°C – 8°C (refrigerated)

• Reconstituted: 4°C for up to 7 days; aliquot and store at -20°C for longer storage; avoid repeated freeze-thaw cycles

Reconstitution Protocol:

1. Allow vial to reach room temperature

2. Add sterile bacteriostatic water or 0.9% sodium chloride solution

3. Gently swirl (do not vortex) until fully dissolved

4. Aliquot for extended storage to minimize freeze-thaw degradation

Note: Peptides are sensitive to formulation, process, and environmental conditions that may lead to aggregation and degradation.

Important Notice

⚠️ FOR RESEARCH USE ONLY

This product is not intended for human consumption, diagnostic use, therapeutic application, or clinical administration. Survodutide is a research chemical intended exclusively for in-vitro and laboratory research purposes.

• Not approved by the FDA for human use

• Not a dietary supplement, food additive, or pharmaceutical for over-the-counter purchase

• Intended solely for qualified researchers and scientific institutions

By purchasing this product, you confirm that you are a licensed researcher or laboratory professional and agree to use this compound in compliance with all applicable local, national, and international regulations.

Why Choose PeptidesUnit.com?

Order Now

Survodutide Peptide 5mg – ≥99% Purity
Available for immediate shipment