Product Overview
Ipamorelin Peptide is a synthetic pentapeptide and a growth hormone secretagogue (GHS) that selectively activates the ghrelin receptor (GHS-R1a) to stimulate growth hormone release from the anterior pituitary. Developed by Novo Nordisk in the late 1990s under the research designation NNC 26-0161, it was the first GHS to demonstrate highly selective GH stimulation without significant elevation of cortisol, ACTH, or prolactin.
As a ghrelin mimetic, Ipamorelin is distinct from earlier GHRPs due to its precise receptor targeting. It is believed to provoke robust GH release comparable to GHRP-6 yet without the collateral stimulation of stress-related hormones. This selectivity makes it a valuable investigative tool for researchers aiming to isolate GH pathways in controlled laboratory settings.
⚠️ Research Context: This product is intended exclusively for in-vitro and laboratory research purposes. It is not FDA-approved for human use and is listed on the WADA Prohibited List (S2.2.4) as a growth hormone secretagogue.
Ipamorelin Peptide Mechanism of Action
Ipamorelin functions through selective activation of the ghrelin receptor (GHS-R1a):
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GHS-R1a Agonism: Binds to ghrelin receptors primarily in GHRH-positive neurons in the hypothalamus and on somatotroph cells in the anterior pituitary.
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Pulsatile GH Release: Triggers the release of growth hormone in a pulsatile pattern that preserves hypothalamic feedback mechanisms.
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Hormonal Selectivity: Ipamorelin was specifically designed to avoid interactions with receptors involved in cortisol, ACTH, or prolactin pathways. Research demonstrates that equimolar doses stimulate GH at levels comparable to GHRP-6 while producing no statistically significant elevation in ACTH or cortisol.
Receptor Activation Effects:
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Growth Hormone Release: Stimulates GH secretion through GHS-R1a activation.
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Gastric Motility: GHS-R1a receptors are also present in the gastrointestinal tract; ipamorelin has been shown to stimulate gastric acid secretion and gastric motility in research models.
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Appetite Regulation: As a ghrelin mimetic, ipamorelin influences food intake and body weight dynamics in animal studies.
Key Research Applications:
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GHS-R receptor pharmacology and signaling studies
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GH axis and pulsatile secretion research
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Endocrine selectivity investigations
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Gastrointestinal motility research
Product Specifications
| Parameter | Specification |
|---|---|
| Product Name | Ipamorelin Peptide |
| Synonyms | NNC-26-0161, Ipamorelin Acetate |
| CAS Number | 170851-70-4 |
| Molecular Formula | C₃₈H₄₉N₉O₅ |
| Molecular Weight | ~711.8 g/mol (free base) |
| Sequence | Aib-His-D-2-Nal-D-Phe-Lys-NH₂ |
| Appearance | White to off-white lyophilized powder |
| Purity | ≥99% (HPLC Verified) |
| Peptide Content | ≥70% |
| Water Content | ≤5.0% |
| Endotoxin Level | <0.25 EU/mg |
| Solubility | Soluble in sterile water (≥1 mg/mL) |
| Storage | -20°C (long-term); 2-8°C (short-term), protected from light and moisture |
Quality Control Specifications
| Test | Method | Specification |
|---|---|---|
| Identity | ESI-MS | Consistent with theoretical mass of 711.86 Da |
| Purity | RP-HPLC | ≥99% area |
| Sequence Confirmation | MS/MS | Confirmed |
| Acetate Content | Ion Chromatography | ≤20.0% |
| Microbial Limits | USP <61>/<62> | <100 CFU/g; no pathogens |
Certificate of Analysis (COA) available upon request.
Research Background
Discovery and Development
Ipamorelin Peptide emerged from a medicinal chemistry program at Novo Nordisk aimed at identifying highly selective growth hormone secretagogues. A 1998 paper published in the European Journal of Endocrinology first described ipamorelin as “the first selective growth hormone secretagogue” — a pentapeptide that released GH in conscious swine with potency comparable to GHRP-6 but without the ACTH, cortisol, or prolactin elevations seen with earlier GHRPs. The structure-activity relationship (SAR) program was detailed in a companion paper in the Journal of Medicinal Chemistry that same year. Ipamorelin Peptide
Selectivity Profile
| Compound | GH Release | Cortisol/ACTH | Prolactin |
|---|---|---|---|
| Ipamorelin | +++ | Minimal | Minimal |
| GHRP-6 | +++ | Elevated | Elevated |
Ipamorelin Peptide’s three-way selectivity — GH stimulation without cortisol, prolactin, or ACTH elevation — established it as the benchmark for GHS selectivity in the academic literature. Ipamorelin Peptide
Preclinical Research Findings
| Research Area | Key Finding |
|---|---|
| GH Release Potency | In vitro EC₅₀ = 1.3 nM; in vivo ED₅₀ = 80 nmol/kg (rats) and 2.3 nmol/kg (swine) |
| Bone Growth | Supports longitudinal bone growth in rat models; tibial growth rates increased from ~42 µm/day to 52 µm/day |
| Gastrointestinal Motility | Accelerated colonic transit and stomach emptying in postoperative ileus models |
| Weight Dynamics | Associated with increased body weight gain and food intake in research models |
Clinical and Regulatory Status
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FDA Status: Not approved for human use. As of September 2023, classified as a Category 2 bulk drug substance under Section 503A of the FD&C Act, prohibiting use in compounded medications for human administration.
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WADA Status: Prohibited both in and out of competition (S2.2.4 – Growth hormone secretagogues).
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Clinical Research: One Phase 2 randomized controlled trial for postoperative ileus (2014) failed to meet its primary endpoint.
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Regulatory: Not listed on the Australian Register of Therapeutic Goods (ARTG).
Storage & Reconstitution Guidelines
Storage Conditions:
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Lyophilized (Long-term): -20°C, protected from light, dry, sealed
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Lyophilized (Short-term): 2°C – 8°C (refrigerated)
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Reconstituted: 4°C for up to 7 days; aliquot for extended storage; avoid repeated freeze-thaw cycles
Reconstitution Protocol:
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Allow vial to reach room temperature
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Add sterile bacteriostatic water or 0.9% sodium chloride solution
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Gently swirl (do not vortex) until fully dissolved
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Dispense into individual aliquots to minimize freeze-thaw degradation
Note: Peptides are sensitive to formulation, process, and environmental conditions that may lead to aggregation and degradation.
Important Notice
⚠️ FOR RESEARCH USE ONLY
This product is not intended for human consumption, diagnostic use, therapeutic application, or clinical administration. Ipamorelin Peptide is a research chemical intended exclusively for in-vitro and laboratory research purposes.
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Not approved by the FDA for human use
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Not a dietary supplement, food additive, or pharmaceutical for over-the-counter purchase
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Prohibited by the World Anti-Doping Agency (WADA S2.2.4)
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Intended solely for qualified researchers and scientific institutions
By purchasing this product, you confirm that you are a licensed researcher or laboratory professional and agree to use this compound in compliance with all applicable local, national, and international regulations.
Why Choose PeptidesUnit.com?
| Feature | Benefit |
|---|---|
| ✅ Premium Purity | ≥99% HPLC-verified purity guaranteed |
| ✅ Research-Grade Quality | Manufactured under GMP-aligned conditions |
| ✅ Third-Party Tested | Independent COA for every batch |
| ✅ Secure Packaging | Lyophilized in amber glass vials with tamper-evident seals |
| ✅ Fast Global Shipping | Discreet packaging with real-time tracking |
| ✅ Competitive Pricing | Direct-from-manufacturer pricing |
Order Now
Ipamorelin Peptide 5mg – ≥99% Purity
Available for immediate shipment. Ipamorelin Peptide
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| Dosage | 5mg, 10mg |
|---|
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