Cagrilintide Peptide 5mg / 10mg (≥99% Purity) – Research Grade Long-Acting Amylin Analog

Cagrilintide Peptide Overview

Cagrilintide Peptide is an investigational long-acting acylated peptide analogue of amylin, a neuroendocrine hormone co-secreted with insulin by pancreatic beta-cells in response to food intake. As a non-selective agonist of amylin receptors (AMYRs) and the calcitonin G protein-coupled receptor (CTR), cagrilintide represents a novel therapeutic class for metabolic research.

The peptide incorporates a fatty acid acylation modification that enables binding to serum albumin, significantly extending its half-life compared to native amylin or earlier analogs such as pramlintide. Cagrilintide is currently in clinical development for weight management and type-2 diabetes, including in fixed-dose combination with semaglutide (CagriSema).

Mechanism of Action

Cagrilintide functions through the activation of amylin receptor subtypes (AMY1-3), which are heterodimers formed by the calcitonin receptor (CTR) and receptor activity-modifying proteins (RAMPs). This signaling pathway regulates:

• Appetite Suppression: Reduces food intake through central mechanisms in brain regions associated with energy homeostasis

• Gastric Emptying: Modulates gastrointestinal motility

• Energy Homeostasis: Influences metabolic regulation and energy expenditure

Key Research Applications:

• Amylin receptor signaling and pathway studies

• Metabolic regulation and energy homeostasis research

• Appetite and satiety mechanism investigations

• Combination therapy research with GLP-1 analogs

• Obesity and type-2 diabetes preclinical models

Cagrilintide Peptide Product Specifications

Quality Assurance

Every batch of Cagrilintide undergoes comprehensive analytical testing to ensure maximum purity and research integrity:

Certificate of Analysis (COA) available upon request.

Storage & Reconstitution Guidelines

Storage Conditions:

• Lyophilized (Long-term): -20°C, protected from light and moisture

• Lyophilized (Short-term): 2°C – 8°C (refrigerated)

• Reconstituted: 4°C for up to 7 days; avoid repeated freeze-thaw cycles

Reconstitution Protocol:

1. Allow vial to reach room temperature

2. Add sterile bacteriostatic water or 0.9% sodium chloride solution

3. Gently swirl (do not vortex) until fully dissolved

4. Allow solution to stand at 4°C for complete reconstitution

Note: Peptides are sensitive to formulation, process, and environmental conditions that may lead to aggregation and degradation. Cagrilintide Peptide

Important Notice

⚠️ FOR RESEARCH USE ONLY

This product is not intended for human consumption, diagnostic use, therapeutic application, or clinical administration. Cagrilintide is a research chemical intended exclusively for in-vitro and laboratory research purposes.

• Not approved by the FDA for human use

• Not a dietary supplement, food additive, or pharmaceutical

• Intended solely for qualified researchers and scientific institutions

By purchasing this product, you confirm that you are a licensed researcher or laboratory professional and agree to use this compound in compliance with all applicable local, national, and international regulations. Cagrilintide Peptide

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Cagrilintide Peptide 5mg – ≥99% Purity
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