NAD+ Peptide (≥99% Purity) – Research Grade Coenzyme
NAD+ Peptide (Nicotinamide Adenine Dinucleotide) is a coenzyme found in all living cells, functioning as an essential electron carrier in redox reactions critical to cellular respiration and ATP production . NAD+ also serves as a substrate for enzymes including sirtuins (SIRT1–SIRT7) and PARPs, which regulate DNA repair, inflammation, and metabolic stress responses . NAD+ Peptide levels naturally decline with age—research suggests a reduction of approximately 50% between ages 20 and 60—creating significant interest in NAD+ restoration research .
This research-grade NAD+ peptide is available in a 500mg lyophilized powder format, offering high purity for laboratory investigations into mitochondrial function, cellular energy metabolism, and age-related metabolic decline.
Mechanism of Action
NAD+ functions through multiple essential cellular pathways:
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Cellular Energy Production: Acts as an electron carrier in the electron transport chain, facilitating mitochondrial ATP production . NAD+ accepts electrons to form NADH, which transfers them to other enzymes to power ATP synthase .
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Sirtuin Activation: Serves as a substrate for sirtuin proteins (SIRT1–SIRT7), which regulate cellular repair, inflammation, and metabolic stress responses .
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DNA Repair Support: Functions as a co-substrate for PARP enzymes, which are critical for DNA damage repair pathways . Depletion of NAD+ Peptide following DNA damage can impair cellular energy production and lead to cell death .
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Mitochondrial Function: Supports maintenance of mitochondrial health and cellular homeostasis .
Key Research Applications:
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Mitochondrial function and cellular energy metabolism studies
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Aging research and age-related metabolic decline
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Neuroprotection and cognitive function research
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Metabolic regulation and insulin sensitivity investigations
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DNA repair and cellular stress response studies
Product Specifications
| Parameter | Specification |
|---|---|
| Product Name | NAD+ (Nicotinamide Adenine Dinucleotide) |
| Synonyms | Beta-NAD, NAD, Endopride, Coenzyme I |
| CAS Number | 53-84-9 |
| Molecular Formula | C₂₁H₂₇N₇O₁₄P₂ |
| Molecular Weight | 663.43 g/mol |
| Purity | ≥99% (HPLC Verified) |
| Form | White to off-white lyophilized powder |
| Storage | -20°C (long-term); 2-8°C (short-term), protected from light and moisture |
| Solubility | Soluble in aqueous solutions |
| Endotoxin Level | <0.25 EU/mg |
Quality Assurance
Every batch of NAD+ Peptide undergoes rigorous analytical testing to ensure maximum purity and research integrity:
| Test | Method | Specification |
|---|---|---|
| Identity | ESI-MS / HPLC | Matches reference standard |
| Purity | RP-HPLC | ≥99% area |
| Sterility | USP <71> | No growth |
| Endotoxin | LAL Test | <0.25 EU/mg |
Certificate of Analysis (COA) available upon request.
Storage & Reconstitution Guidelines
Storage Conditions:
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Lyophilized (Long-term): -20°C, dry, protected from light and moisture
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Lyophilized (Short-term): 2°C – 8°C (refrigerated)
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Reconstituted: 4°C for up to 7 days; aliquot and store at -20°C for longer storage; avoid repeated freeze-thaw cycles
Reconstitution Protocol:
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Allow vial to reach room temperature
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Add sterile bacteriostatic water or 0.9% sodium chloride solution
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Gently swirl until fully dissolved
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Dispense into individual aliquots to minimize freeze-thaw degradation
Research Background
NAD+ Decline and Cellular Aging
Research suggests NAD+ Peptide levels decline substantially with age, with approximately a 50% reduction by age 60 . This decline is attributed to reduced synthesis and increased consumption by proteins like sirtuins and PARPs, contributing to age-related mitochondrial dysfunction .
NAD+ vs. Precursors (NMN, NR)
NAD+ peptide compounds differ mechanistically from direct precursors like NMN and NR, which provide substrate for NAD+ synthesis via salvage pathways. Peptide-based approaches may offer distinct tissue penetration, stability, and signaling characteristics for research applications .
| Category | Mechanism | Research Status |
|---|---|---|
| NAD+ Peptides | Support NAD+ synthesis via receptor signaling or enzymatic pathways | Early human trials; limited long-term data |
| NMN | Direct salvage-pathway substrate | Phase 2 human trials ongoing |
| NR | Direct salvage-pathway substrate | More human trial data available |
Neuroprotection Research
Recent research has explored NAD+ Peptide delivery strategies for acute brain injury models. Studies using nanopeptoid delivery systems have demonstrated that NAD+ restoration can enhance cell viability and replenish ATP levels in oxygen-glucose deprived brain cells, with potential applications in stroke, traumatic brain injury, and neonatal hypoxic-ischemic injury research .
Important Notice
⚠️ FOR RESEARCH USE ONLY
This product is not intended for human consumption, diagnostic use, therapeutic application, or clinical administration. NAD+ is a research chemical intended exclusively for in-vitro and laboratory research purposes .
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Not approved by the FDA for human use
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Not a dietary supplement, food additive, or pharmaceutical
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Clinical research suggests NAD+ peptides remain investigational in most contexts, with incomplete human safety data
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Intended solely for qualified researchers and scientific institutions
By purchasing this product, you confirm that you are a licensed researcher or laboratory professional and agree to use this compound in compliance with all applicable local, national, and international regulations.
Why Choose PeptidesUnit.com?
| Feature | Benefit |
|---|---|
| ✅ Premium Purity | ≥99% HPLC-verified purity guaranteed |
| ✅ Research-Grade Quality | Manufactured under GMP-aligned conditions |
| ✅ Third-Party Tested | Independent COA for every batch |
| ✅ Secure Packaging | Lyophilized in amber glass vials with tamper-evident seals |
| ✅ Fast Global Shipping | Discreet packaging with real-time tracking |
| ✅ Competitive Pricing | Direct-from-manufacturer pricing |
Order Now
NAD+ Peptide 500mg – ≥99% Purity
Available for immediate shipment
| Dosage | 100mg, 500mg, 1000mg |
|---|
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