Product Overview
CJC-1295 without DAC (also known as Modified GRF 1-29 or Mod GRF) is a synthetic 29-amino acid peptide analogue of Growth Hormone-Releasing Hormone (GHRH) . Unlike its counterpart containing a Drug Affinity Complex (DAC), this “no DAC” version features a lysine deletion at the C-terminus, resulting in a much shorter half-life .
The “no DAC” form is specifically designed to support research requiring a physiologic, pulsatile release pattern of growth hormone, closely mimicking the body’s natural secretory rhythm . This approach may be preferred in research models where sustained, continuous GH elevation is not desired . CJC-1295 without DAC
Mechanism of Action
CJC-1295 without DAC functions as a GHRH receptor agonist:
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Pituitary Binding: Binds to GHRH receptors on pituitary somatotroph cells
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Pulsatile GH Release: Stimulates the release of growth hormone in a pulsatile manner that emulates natural secretion patterns
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Short Duration: The absence of DAC yields an approximate half-life of 30 minutes, preserving physiologic GH pulsatility
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Receptor Sensitivity: Shorter half-life may reduce risk of receptor desensitization
Key Research Applications:
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Pulsatile growth hormone release dynamics
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GHRH receptor signaling and function studies
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Pituitary function and regulation research
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Synergistic research with GHRPs (e.g., Ipamorelin)
Product Specifications
| Parameter | Specification |
|---|---|
| Product Name | CJC-1295 (No DAC) / Modified GRF 1-29 |
| Synonyms | CJC-1295-no DAC, Mod GRF 1-29, GHRH (1-29)-NH2 |
| CAS Number | 863288-34-0 |
| Molecular Formula | C₁₅₂H₂₅₂N₄₄O₄₂ |
| Molecular Weight | 3,367.9 g/mol |
| Purity | ≥99% (HPLC Verified) |
| Form | White to off-white lyophilized powder |
| Peptide Content | ≥70% |
| Endotoxin Level | <0.25 EU/mg |
| Storage | -20°C (long-term); 2-8°C (short-term), protected from light and moisture |
Quality Assurance
Every batch undergoes rigorous analytical testing to ensure maximum purity and research integrity:
| Test | Method | Specification |
|---|---|---|
| Identity | ESI-MS | Matches theoretical mass |
| Purity | RP-HPLC | ≥99% area |
| Sequence Confirmation | MS/MS | 100% sequence coverage |
| Endotoxin | LAL Test | <0.25 EU/mg |
Certificate of Analysis (COA) available upon request.
Storage & Reconstitution Guidelines
Storage Conditions:
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Lyophilized (Long-term): -20°C, protected from light and moisture
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Lyophilized (Short-term): 2°C – 8°C (refrigerated)
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Reconstituted: 4°C for up to 7 days; aliquot for extended storage; avoid repeated freeze-thaw cycles
Reconstitution Protocol:
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Allow vial to reach room temperature
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Add sterile bacteriostatic water or 0.9% sodium chloride solution
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Gently swirl (do not vortex) until fully dissolved
Note: Peptides are sensitive to formulation, process, and environmental conditions that may lead to aggregation and degradation. CJC-1295 without DAC
Research Background
CJC-1295 No DAC vs. With DAC
| Feature | CJC-1295 No DAC | CJC-1295 With DAC |
|---|---|---|
| Half-Life | ~30 minutes | 6-8 days |
| GH Release Pattern | Pulsatile (natural) | Sustained elevation |
| Dosing Frequency | 1-3x daily | 1-2x weekly |
| Receptor Risk | Lower risk of desensitization | Higher risk of desensitization |
Research Context
CJC-1295 without DAC has been referenced in scientific literature since at least 2010 . It is often studied in combination with growth hormone secretagogues like Ipamorelin for research into synergistic effects on pulsatile GH release . CJC-1295 without DAC
Important Notice
⚠️ FOR RESEARCH USE ONLY
This product is not intended for human consumption, diagnostic use, therapeutic application, or clinical administration. CJC-1295 is a research chemical intended exclusively for in-vitro and laboratory research purposes .
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Not approved by the FDA for human use
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Not a dietary supplement, food additive, or pharmaceutical
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Intended solely for qualified researchers and scientific institutions
By purchasing this product, you confirm that you are a licensed researcher or laboratory professional and agree to use this compound in compliance with all applicable local, national, and international regulations.
Why Choose PeptidesUnit.com?
| Feature | Benefit |
|---|---|
| ✅ Premium Purity | ≥99% HPLC-verified purity guaranteed |
| ✅ Research-Grade Quality | Manufactured under GMP-aligned conditions |
| ✅ Third-Party Tested | Independent COA for every batch |
| ✅ Secure Packaging | Lyophilized in amber glass vials with tamper-evident seals |
| ✅ Fast Global Shipping | Discreet packaging with real-time tracking |
| ✅ Competitive Pricing | Direct-from-manufacturer pricing |
Order Now
CJC-1295 (No DAC) Peptide 5mg – ≥99% Purity
Available for immediate shipment
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| Dosage | 2mg, 5mg, 10mg |
|---|
39 reviews for CJC-1295 (No DAC)
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