NAD+ Peptide (≥99% Purity) – Research Grade Coenzyme

NAD+ Peptide (Nicotinamide Adenine Dinucleotide) is a coenzyme found in all living cells, functioning as an essential electron carrier in redox reactions critical to cellular respiration and ATP production . NAD+ also serves as a substrate for enzymes including sirtuins (SIRT1–SIRT7) and PARPs, which regulate DNA repair, inflammation, and metabolic stress responses . NAD+ Peptide levels naturally decline with age—research suggests a reduction of approximately 50% between ages 20 and 60—creating significant interest in NAD+ restoration research .

This research-grade NAD+ peptide is available in a 500mg lyophilized powder format, offering high purity for laboratory investigations into mitochondrial function, cellular energy metabolism, and age-related metabolic decline.

Mechanism of Action

NAD+ functions through multiple essential cellular pathways:

• Cellular Energy Production: Acts as an electron carrier in the electron transport chain, facilitating mitochondrial ATP production . NAD+ accepts electrons to form NADH, which transfers them to other enzymes to power ATP synthase .

• Sirtuin Activation: Serves as a substrate for sirtuin proteins (SIRT1–SIRT7), which regulate cellular repair, inflammation, and metabolic stress responses .

• DNA Repair Support: Functions as a co-substrate for PARP enzymes, which are critical for DNA damage repair pathways . Depletion of NAD+ Peptide following DNA damage can impair cellular energy production and lead to cell death .

• Mitochondrial Function: Supports maintenance of mitochondrial health and cellular homeostasis .

Key Research Applications:

• Mitochondrial function and cellular energy metabolism studies

• Aging research and age-related metabolic decline

• Neuroprotection and cognitive function research

• Metabolic regulation and insulin sensitivity investigations

• DNA repair and cellular stress response studies

Product Specifications

Quality Assurance

Every batch of NAD+ Peptide undergoes rigorous analytical testing to ensure maximum purity and research integrity:

Certificate of Analysis (COA) available upon request.

Storage & Reconstitution Guidelines

Storage Conditions:

• Lyophilized (Long-term): -20°C, dry, protected from light and moisture 

• Lyophilized (Short-term): 2°C – 8°C (refrigerated)

• Reconstituted: 4°C for up to 7 days; aliquot and store at -20°C for longer storage; avoid repeated freeze-thaw cycles

Reconstitution Protocol:

1. Allow vial to reach room temperature

2. Add sterile bacteriostatic water or 0.9% sodium chloride solution

3. Gently swirl until fully dissolved

4. Dispense into individual aliquots to minimize freeze-thaw degradation

Research Background

NAD+ Decline and Cellular Aging

Research suggests NAD+ Peptide levels decline substantially with age, with approximately a 50% reduction by age 60 . This decline is attributed to reduced synthesis and increased consumption by proteins like sirtuins and PARPs, contributing to age-related mitochondrial dysfunction .

NAD+ vs. Precursors (NMN, NR)

NAD+ peptide compounds differ mechanistically from direct precursors like NMN and NR, which provide substrate for NAD+ synthesis via salvage pathways. Peptide-based approaches may offer distinct tissue penetration, stability, and signaling characteristics for research applications .

Neuroprotection Research

Recent research has explored NAD+ Peptide delivery strategies for acute brain injury models. Studies using nanopeptoid delivery systems have demonstrated that NAD+ restoration can enhance cell viability and replenish ATP levels in oxygen-glucose deprived brain cells, with potential applications in stroke, traumatic brain injury, and neonatal hypoxic-ischemic injury research .

Important Notice

⚠️ FOR RESEARCH USE ONLY

This product is not intended for human consumption, diagnostic use, therapeutic application, or clinical administration. NAD+ is a research chemical intended exclusively for in-vitro and laboratory research purposes .

• Not approved by the FDA for human use

• Not a dietary supplement, food additive, or pharmaceutical

• Clinical research suggests NAD+ peptides remain investigational in most contexts, with incomplete human safety data 

• Intended solely for qualified researchers and scientific institutions

By purchasing this product, you confirm that you are a licensed researcher or laboratory professional and agree to use this compound in compliance with all applicable local, national, and international regulations.

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NAD+ Peptide 500mg – ≥99% Purity
Available for immediate shipment